Tryptophan and hepatic coma

Jiroichi Ono, Duane Hutson, Roy S. Dombro, Joe Levi, Alan Livingstone, Robert Zeppa

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

To clarify the involvement of tryptophan in the pathogenesis of hepatic coma, plasma and cerebrospinal fluid (CSF) tryptophan was studied in three patient groups (hepatic coma, stable cirrhosis, and control). An assessment of free fatty acids, some of the amino acids reported to compete with tryptophan for brain uptake, and albumin was also made. The data demonstrated that, whereas the elevated CSF tryptophan levels in cirrhotic patients compared to controls may have been attributable to decreased plasma branched chain amino acids, the elevated CSF tryptophan levels in hepatic coma compared to stable cirrhotic patients were probably attributable to increased plasma free tryptophan concentrations. Associated with the elevated plasma free tryptophan in coma patients was an increase in plasma free fatty acids and a marked decrease in serum albumin levels. Of all the amino acids investigated in the CSF, only tryptophan was significantly increased in patients in hepatic coma compared to cirrhotic patients not in coma.

Original languageEnglish
Pages (from-to)196-200
Number of pages5
JournalGastroenterology
Volume74
Issue number2 PART 1
StatePublished - Jan 1 1978

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Hepatic Encephalopathy
Tryptophan
Cerebrospinal Fluid
Coma
Nonesterified Fatty Acids
Amino Acids
Branched Chain Amino Acids
Serum Albumin
Albumins
Fibrosis
Brain

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Ono, J., Hutson, D., Dombro, R. S., Levi, J., Livingstone, A., & Zeppa, R. (1978). Tryptophan and hepatic coma. Gastroenterology, 74(2 PART 1), 196-200.

Tryptophan and hepatic coma. / Ono, Jiroichi; Hutson, Duane; Dombro, Roy S.; Levi, Joe; Livingstone, Alan; Zeppa, Robert.

In: Gastroenterology, Vol. 74, No. 2 PART 1, 01.01.1978, p. 196-200.

Research output: Contribution to journalArticle

Ono, J, Hutson, D, Dombro, RS, Levi, J, Livingstone, A & Zeppa, R 1978, 'Tryptophan and hepatic coma', Gastroenterology, vol. 74, no. 2 PART 1, pp. 196-200.
Ono J, Hutson D, Dombro RS, Levi J, Livingstone A, Zeppa R. Tryptophan and hepatic coma. Gastroenterology. 1978 Jan 1;74(2 PART 1):196-200.
Ono, Jiroichi ; Hutson, Duane ; Dombro, Roy S. ; Levi, Joe ; Livingstone, Alan ; Zeppa, Robert. / Tryptophan and hepatic coma. In: Gastroenterology. 1978 ; Vol. 74, No. 2 PART 1. pp. 196-200.
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