TRPs in taste and chemesthesis

Research output: Chapter in Book/Report/Conference proceedingChapter

55 Scopus citations

Abstract

TRP channels are expressed in taste buds, nerve fibers, and keratinocytes in the oronasal cavity. These channels play integral roles in transducing chemical stimuli, giving rise to sensations of taste, irritation, warmth, coolness, and pungency. Specifically, TRPM5 acts downstream of taste receptors in the taste transduction pathway. TRPM5 channels convert taste-evoked intracellular Ca2+ release into membrane depolarization to trigger taste transmitter secretion. PKD2L1 is expressed in acid-sensitive (sour) taste bud cells but is unlikely to be the transducer for sour taste. TRPV1 is a receptor for pungent chemical stimuli such as capsaicin and for several irritants (chemesthesis). It is controversial whether TRPV1 is present in the taste buds and plays a direct role in taste. Instead, TRPV1 is expressed in non-gustatory sensory afferent fibers and in keratinocytes of the oronasal cavity. In many sensory fibers and epithelial cells lining the oronasal cavity, TRPA1 is also co-expressed with TRPV1. As with TRPV1, TRPA1 transduces a wide variety of irritants and, in combination with TRPV1, assures that there is a broad response to noxious chemical stimuli. Other TRP channels, including TRPM8, TRPV3, and TRPV4, play less prominent roles in chemesthesis and no known role in taste, per se. The pungency of foods and beverages is likely highly influenced by the temperature at which they are consumed, their acidity, and, for beverages, their carbonation. All these factors modulate the activity of TRP channels in taste buds and in the oronasal mucosa.

Original languageEnglish (US)
Title of host publicationMammalian Transient Receptor Potential (TRP) Cation Channels
Subtitle of host publicationVolume II
PublisherSpringer New York LLC
Pages827-871
Number of pages45
ISBN (Print)9783319051604
DOIs
StatePublished - 2014

Publication series

NameHandbook of Experimental Pharmacology
Volume223
ISSN (Print)0171-2004
ISSN (Electronic)1865-0325

Keywords

  • Carbonated sodas
  • Chemesthesis
  • Gustation
  • Irritants
  • Oronasal cavity
  • Salty
  • Sour
  • Spices
  • TRPA1
  • TRPM5
  • TRPV1
  • Trigeminal

ASJC Scopus subject areas

  • Biochemistry
  • Pharmacology, Toxicology and Pharmaceutics(all)

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  • Cite this

    Roper, S. D. (2014). TRPs in taste and chemesthesis. In Mammalian Transient Receptor Potential (TRP) Cation Channels: Volume II (pp. 827-871). (Handbook of Experimental Pharmacology; Vol. 223). Springer New York LLC. https://doi.org/10.1007/978-3-319-05161-1_5