TRP channels in Cutaneous Biology in health and disease

Tamás Bíró, Ralf Paus

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Recent research progress has revealed that numerous transient receptor potential (TRP) channels are not only expressed on sensory afferent endings in human and murine skin, but, intriguingly, also on various non-neuronal skin cell populations such as mast cells, keratinocytes, and sebocytes. These TRP channels have now become implicated in an increasing variety of cutaneous functions. In this chapter, we focus on delineating the physiological regulatory function of TRP channels in skin-derived pruritus (pruritoceptive itch) and in the control of proliferation, differentiation, apoptosis, and cytokine/mediator production of various cell types of the skin and its appendages (e.g. hair follicle, sebaceous gland). Moreover, we discuss the emerging evidence that selected TRP channels are also involved in skin diseases, such as e.g. in skin carcinogenesis and skin tumor growth, acne, seborrhea, psoriasis, and hair growth disorders. We close by delineating some important future basic and clinical research directions and strategies that are geared towards the therapeutic targeting of defined TRP channels for the management of skin disorders.

Original languageEnglish (US)
Title of host publicationTRP Channels in Health and Disease
Subtitle of host publicationImplications for Diagnosis and Therapy
PublisherNova Science Publishers, Inc.
Pages331-362
Number of pages32
ISBN (Electronic)9781620818121
ISBN (Print)9781616683375
StatePublished - Jul 1 2011
Externally publishedYes

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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    Bíró, T., & Paus, R. (2011). TRP channels in Cutaneous Biology in health and disease. In TRP Channels in Health and Disease: Implications for Diagnosis and Therapy (pp. 331-362). Nova Science Publishers, Inc..