Tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM)

Treatment with an anabolic steroid danazol

W. J. Harrington, William Sheremata, S. R. Snodgrass, S. Emerson, S. Phillips, J. R. Berger

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Tropical spastic paraparesis or HTLV-I-associated myelopathy is a progressive spastic disorder associated with the human T-lymphotropic virus type I. Some cases have responded to prednisone. Danazol is an attenuated androgen with minimal virilizing effects. It is used in the treatment of endometriosis and various autoimmune hematologic diseases shown to be responsive to prednisone. Because danazol is anabolic, useful in prednisone-responsive diseases, and less toxic than prednisone, we gave danazol to 6 patients with TSP and 1 with HIV, HTLV-I-associated myelopathy. Five patients had a favorable response. Two became ambulatory after having been confined to a wheelchair. Three were able to ambulate greater distances (in walkers) than prior to danazol. Three had noticable decreases in spasticity. Urinary incontinence resolved in two. Physical therapy was variably employed in all except one patient. Two patients who had not responded to physical therapy responded to physical therapy and danazol. One patient did not tolerate danazol and one patient did not improve. Toxicities noted were mild elevations in liver enzymes in 4 patients; these responded to a decrease in dose of danazol; amenorrhea in one and mild fluid retention in one. We conclude that danazol is a useful agent in the management of TSP.

Original languageEnglish
Pages (from-to)1031-1034
Number of pages4
JournalAIDS Research and Human Retroviruses
Volume7
Issue number12
StatePublished - Dec 1 1991

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Testosterone Congeners
Tropical Spastic Paraparesis
Danazol
Human T-lymphotropic virus 1
Spinal Cord Diseases
Prednisone
Therapeutics
Walkers
Thrombospondin 1
Wheelchairs
Muscle Spasticity
Hematologic Diseases
Poisons
Amenorrhea
Urinary Incontinence
Endometriosis
Androgens
Autoimmune Diseases
HIV-1
Viruses

ASJC Scopus subject areas

  • Immunology
  • Virology

Cite this

Harrington, W. J., Sheremata, W., Snodgrass, S. R., Emerson, S., Phillips, S., & Berger, J. R. (1991). Tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM): Treatment with an anabolic steroid danazol. AIDS Research and Human Retroviruses, 7(12), 1031-1034.

Tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM) : Treatment with an anabolic steroid danazol. / Harrington, W. J.; Sheremata, William; Snodgrass, S. R.; Emerson, S.; Phillips, S.; Berger, J. R.

In: AIDS Research and Human Retroviruses, Vol. 7, No. 12, 01.12.1991, p. 1031-1034.

Research output: Contribution to journalArticle

Harrington, WJ, Sheremata, W, Snodgrass, SR, Emerson, S, Phillips, S & Berger, JR 1991, 'Tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM): Treatment with an anabolic steroid danazol', AIDS Research and Human Retroviruses, vol. 7, no. 12, pp. 1031-1034.
Harrington WJ, Sheremata W, Snodgrass SR, Emerson S, Phillips S, Berger JR. Tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM): Treatment with an anabolic steroid danazol. AIDS Research and Human Retroviruses. 1991 Dec 1;7(12):1031-1034.
Harrington, W. J. ; Sheremata, William ; Snodgrass, S. R. ; Emerson, S. ; Phillips, S. ; Berger, J. R. / Tropical spastic paraparesis/HTLV-1-associated myelopathy (TSP/HAM) : Treatment with an anabolic steroid danazol. In: AIDS Research and Human Retroviruses. 1991 ; Vol. 7, No. 12. pp. 1031-1034.
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