TY - JOUR
T1 - Trophoblastic pseudotumor-Evidence of malignant disease potential
AU - Twiggs, Leo B.
AU - Okagaki, Takashi
AU - Phillips, George L.
AU - Stroemer, John R.
AU - Adcock, Leon L.
N1 - Funding Information:
’ Supported by Minnesota Clinical Cancer Education Program 5R25-CA-1952744. * Presented at the Western Association of Gynecologic Oncology, Lake Tahoe, Nevada, May 29, 1980. ’ To whom reprint requests should be addressed.
PY - 1981/10
Y1 - 1981/10
N2 - Trophoblastic pseudotumor, the histopathologic entity described by Kurman and associates (R. J. Kurman, R. E. Scully, and H. J. Norris, Cancer 38, 1214-1226 (1976)), has been considered in the scheme of gestational trophoblastic neoplasia as an exaggerated form of syncytial endometritis and, therefore, associated with a benign outcome. The manifestation of malignant sequalae and ultimate demise of a patient in a recognized case of trophoblastic pseudotumor is presented. Light and electron microscopic studies and autopsy findings are discussed. Therapies, both surgical and chemotherapeutic, and serum assay of the β subunit of human chorionic gonadotropin are correlated to the clinical course.
AB - Trophoblastic pseudotumor, the histopathologic entity described by Kurman and associates (R. J. Kurman, R. E. Scully, and H. J. Norris, Cancer 38, 1214-1226 (1976)), has been considered in the scheme of gestational trophoblastic neoplasia as an exaggerated form of syncytial endometritis and, therefore, associated with a benign outcome. The manifestation of malignant sequalae and ultimate demise of a patient in a recognized case of trophoblastic pseudotumor is presented. Light and electron microscopic studies and autopsy findings are discussed. Therapies, both surgical and chemotherapeutic, and serum assay of the β subunit of human chorionic gonadotropin are correlated to the clinical course.
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U2 - 10.1016/0090-8258(81)90153-0
DO - 10.1016/0090-8258(81)90153-0
M3 - Article
C2 - 6271654
AN - SCOPUS:0019818589
VL - 12
SP - 238
EP - 248
JO - Gynecologic Oncology
JF - Gynecologic Oncology
SN - 0090-8258
IS - 2
ER -