TrkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues

L. Tessarollo, P. Tsoulfas, D. Martin-Zanca, D. J. Gilbert, N. A. Jenkins, N. G. Copeland, L. F. Parada

Research output: Contribution to journalArticle

249 Scopus citations

Abstract

The Trk family of tyrosine kinases encodes receptors for nerve growth factor-related neurotrophins. Here we present a developmental expression study of trkC, which encodes a receptor for neurotrophin-3 (NT-3). Like the related genes, trk and trkB, trkC is expressed primarily in neural lineages although the pattern is complex and includes non-neuronal cells. Direct comparison with trk and trkB developmental expression patterns permits the following observations. (1) trkC is expressed in novel neural tissues where other Trk genes are silent. (2) Some tissues appear to coexpress trkB and trkC receptors in the embryo and in the adult. (3) trkC expression can be detected in the gastrulating embryo. These data provide insights into the role of Trk-family receptors and nerve growth factor-related neurotrophins during development and suggest that, in addition to regulating neuronal survival and differentiation, the neurotrophin/Trk receptor system may have broader physiological effects. Finally, interspecific mouse backcrosses have been used to map the location of each of the TrA: genes on mouse chromosomes. Alignment with available chromosomal maps identify possible linkage between the TrA genes and known neurological mutations.

Original languageEnglish (US)
Pages (from-to)463-475
Number of pages13
JournalDevelopment
Volume118
Issue number2
StatePublished - Jan 1 1993
Externally publishedYes

Keywords

  • Mouse nervous system
  • Neural development, neurotrophin
  • NT-3
  • trkC
  • Tyrosine kinase

ASJC Scopus subject areas

  • Cell Biology
  • Anatomy

Fingerprint Dive into the research topics of 'TrkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues'. Together they form a unique fingerprint.

  • Cite this

    Tessarollo, L., Tsoulfas, P., Martin-Zanca, D., Gilbert, D. J., Jenkins, N. A., Copeland, N. G., & Parada, L. F. (1993). TrkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. Development, 118(2), 463-475.