Trisomy 7 in non-neoplastic tubular epithelial cells of the kidney

Sakari Knuutila, Marcelo L. Larramendy, Peter Elfving, Wa'el El-Rifai, Aaro Miettinen, Felix Mitelman

Research output: Contribution to journalArticlepeer-review

23 Scopus citations


The cellular origin of trisomy 7 in non-neoplastic kidney tissue specimens from 10 patients, seven with malignant tumors and three with non-neoplastic kidney diseases, was studied by the MAC (morphology antibody chromosomes) technique, which allows analysis of cellular morphology/histology, immunophenotype, and chromosomal aneuploidy by conventional cytogenetics, and/or fluorescent in situ hybridization in both interphase and mitotic cells. In primary cultures, trisomy 7 was detected primarily in cytokeratin-positive cells. Among freshly isolated renal cells, the trisomy was mainly observed in proximal tubular cells positive to brush-border antigen, and, to a lesser extent, in distal tubular cells positive to Tamm-Horsfall glycoprotein. The frequency of trisomy 7 in lymphocytes expressing CD3 or CD22 antigens isolated from non-neoplastic and tumor tissues was substantially lower than in the epithelial cells and was not increased compared with that in control lymphocytes from peripheral blood. The results thus demonstrate that the non-neoplastic kidney cells with trisomy 7 are mainly normal epithelial cells, preferentially those of the proximal tubule.

Original languageEnglish (US)
Pages (from-to)149-156
Number of pages8
JournalHuman Genetics
Issue number2
StatePublished - Feb 1 1995
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


Dive into the research topics of 'Trisomy 7 in non-neoplastic tubular epithelial cells of the kidney'. Together they form a unique fingerprint.

Cite this