Trisomy 5 and trisomy 7 are nonrandom aberrations in pigmented villonodular synovitis: Confirmation of trisomy 7 in uncultured cells

Jonathan A. Fletcher, Carol Henkle, Leonard Atkins, Andrew E. Rosenberg, Cynthia C. Morton

Research output: Contribution to journalArticle

81 Scopus citations


Pigmented villonodular synovitis (PVNS) is a proliferative lesion of disputed genesis. Recently, we reported trisomy 7 in short-term cultures of I PVNS. In the present report, we describe another specimen of PVNS in which 9 of 26 (35 percent) metaphase cells demonstrated trisomy 7 when analyzed after 3-15 days of tissue culture. In situ hybridization analysis, with a biotinylated probe to chromosome 7 alpha-satellite DNA, revealed trisomy 7 in 53 of 200 uncultured cells from this PVNS sample. Our findings indicate that trisomy 7 is a nonrandom aberration that arises in vivo in PVNS.

Original languageEnglish (US)
Pages (from-to)264-266
Number of pages3
JournalGenes, Chromosomes and Cancer
Issue number3
StatePublished - Apr 1992
Externally publishedYes


ASJC Scopus subject areas

  • Genetics
  • Cancer Research

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