Trisomy 5 and trisomy 7 are nonrandom aberrations in pigmented villonodular synovitis

Confirmation of trisomy 7 in uncultured cells

J. A. Fletcher, C. Henkle, L. Atkins, Andrew Rosenberg, C. C. Morton

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Pigmented villonodular synovitis (PVNS) is a proliferative lesion of disputed genesis. Recently, we reported trisomy 7 in short-term cultures of I PVNS. In the present report, we describe another specimen of PVNS in which 9 of 26 (35 percent) metaphase cells demonstrated trisomy 7 when analyzed after 3-15 days of tissue culture. In situ hybridization analysis, with a biotinylated probe to chromosome 7 alpha-satellite DNA, revealed trisomy 7 in 53 of 200 uncultured cells from this PVNS sample. Our findings indicate that trisomy 7 is a nonrandom aberration that arises in vivo in PVNS.

Original languageEnglish
Pages (from-to)264-266
Number of pages3
JournalGenes Chromosomes and Cancer
Volume4
Issue number3
DOIs
StatePublished - May 15 1992
Externally publishedYes

Fingerprint

Pigmented Villonodular Synovitis
Trisomy
Satellite DNA
Chromosomes, Human, Pair 7
Metaphase
In Situ Hybridization

ASJC Scopus subject areas

  • Cancer Research
  • Genetics

Cite this

Trisomy 5 and trisomy 7 are nonrandom aberrations in pigmented villonodular synovitis : Confirmation of trisomy 7 in uncultured cells. / Fletcher, J. A.; Henkle, C.; Atkins, L.; Rosenberg, Andrew; Morton, C. C.

In: Genes Chromosomes and Cancer, Vol. 4, No. 3, 15.05.1992, p. 264-266.

Research output: Contribution to journalArticle

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