Triiodothyronine (T3) nuclear binding sites in human placenta and decidua

K. Banovac, E. A. Ryan, M. J. O'Sullivan

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

We studied the binding of triiodothyronine (T3) to human placenta and decidua. Although the placenta effectively blocks transfer of thyroxine (T4) and T3 it may itself be a thyroid hormone-dependent tissue and may specifically bind T3. A single class of high-affinity binding sites was found (K(a) 3.8 ± 0.31 s.e.m., and 3.3 ± 109 M-1) for both placenta and decidua. Limited capacity was also observed, viz., 0.117 ± 0.01 and 0.102 ± 0.018 fmoles/μg deoxyribonucleic acid (DNA), respectively. Endogenous T3 nuclear saturation was 34%. Our results are consistent with the proposal that placenta and decidua have similar T3 specific nuclear binding sites and that T3 may have a direct action in the placenta.

Original languageEnglish
Pages (from-to)543-549
Number of pages7
JournalPlacenta
Volume7
Issue number6
StatePublished - Dec 1 1986
Externally publishedYes

Fingerprint

Decidua
Triiodothyronine
Placenta
Binding Sites
Thyroxine
Thyroid Hormones
DNA

ASJC Scopus subject areas

  • Obstetrics and Gynecology

Cite this

Banovac, K., Ryan, E. A., & O'Sullivan, M. J. (1986). Triiodothyronine (T3) nuclear binding sites in human placenta and decidua. Placenta, 7(6), 543-549.

Triiodothyronine (T3) nuclear binding sites in human placenta and decidua. / Banovac, K.; Ryan, E. A.; O'Sullivan, M. J.

In: Placenta, Vol. 7, No. 6, 01.12.1986, p. 543-549.

Research output: Contribution to journalArticle

Banovac, K, Ryan, EA & O'Sullivan, MJ 1986, 'Triiodothyronine (T3) nuclear binding sites in human placenta and decidua', Placenta, vol. 7, no. 6, pp. 543-549.
Banovac K, Ryan EA, O'Sullivan MJ. Triiodothyronine (T3) nuclear binding sites in human placenta and decidua. Placenta. 1986 Dec 1;7(6):543-549.
Banovac, K. ; Ryan, E. A. ; O'Sullivan, M. J. / Triiodothyronine (T3) nuclear binding sites in human placenta and decidua. In: Placenta. 1986 ; Vol. 7, No. 6. pp. 543-549.
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