Triglyceride-lowering therapies reduce cardiovascular disease event risk in subjects with hypertriglyceridemia

Kevin C. Maki, John R. Guyton, Carl E. Orringer, Ian Hamilton-Craig, Dominik D. Alexander, Michael H. Davidson

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


Background Cardiovascular outcomes trials of fibrates, niacin, or omega-3 fatty acids alone, or added to a statin, have not consistently demonstrated reduced risk, but larger, statistically significant clinical benefits have been reported in subgroups with elevated triglycerides (TG) and/or elevated TG plus low high-density lipoprotein cholesterol (HDL-C). Objective To perform a meta-analysis of the effects of therapies targeting TG and TG-rich lipoprotein cholesterol on cardiovascular disease event risk in subjects with elevated TG or elevated TG paired with low HDL-C. Methods Publications were identified using PubMed, the Cochrane Central Register of Controlled Trials,, the World Health Organization International Clinical Trials Registry Platform, and Internet Stroke Center. Random-effects meta-analysis models were used to generate summary relative risk estimates and 95% confidence intervals. Heterogeneity was assessed by χ2 and I2 statistics, and the impact of each trial was assessed in one study–removed sensitivity analyses. Results Six trials of fibrates, 2 of niacin, 1 of fibrate + niacin, and 1 of omega-3 eicosapentaenoic acid ethyl esters were identified. For the prespecified primary cardiovascular disease or coronary heart disease end point used in each trial, the summary relative risk estimate (95% confidence interval) for subjects with elevated TG was 0.82 (0.73–0.91), p-heterogeneity = 0.13, I2 = 36.2, and for subjects with elevated TG and low-HDL-C, it was 0.71 (0.63–0.81), p-heterogeneity = 0.52, I2 = 0.0. There was no evidence of publication bias, and the results remained statistically significant when each individual trial was removed. Conclusion Drugs that substantially, but not exclusively, lower TG and TG-rich lipoprotein cholesterol may have cardiovascular benefits in individuals with elevated TG, particularly if accompanied by low HDL-C.

Original languageEnglish (US)
Pages (from-to)905-914
Number of pages10
JournalJournal of Clinical Lipidology
Issue number4
StatePublished - Jul 1 2016


  • Cardiovascular disease
  • Cardiovascular events
  • Fibrates
  • Hypertriglyceridemia
  • Lipid-altering drug therapy
  • Niacin
  • Omega-3 fatty acids
  • Triglyceride-lowering therapy

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics
  • Cardiology and Cardiovascular Medicine


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