Triazolophanes: A new class of halide-selective lonophores for potentiometrie sensors

Elsayed M. Zahran, Yuran Hua, Yongjun Li, Amar H. Flood, Leonidas G. Bachas

Research output: Contribution to journalArticlepeer-review

45 Scopus citations

Abstract

Triazolophanes, cyclic compounds containing 1,2,3-triazole units, are a new class of host molecules that demonstrate strong interactions with halides. These molecules are designed with a preorganized cavity that interacts through hydrogen bonding with spherical anions, such as chloride and bromide. We have explored the use of one such triazolophane as a halide-selective ionophore in poly(vinyl chloride) (PVC) membrane electrodes. Different membrane compositions were evaluated to identify concentrations of the ionophore, plasticizer, and lipophilic additive that give rise to the best chloride and bromide selectivity. The lipophilicity of the plasticizer was found to have a great impact on the electrode response. Additionally, the concentration of the lipophilic additive was found to be critical for optimal response. The utility of a triazolophane-based electrode was demonstrated by quantification of bromide in horse serum samples.

Original languageEnglish (US)
Pages (from-to)368-375
Number of pages8
JournalAnalytical Chemistry
Volume82
Issue number1
DOIs
StatePublished - Feb 8 2010
Externally publishedYes

ASJC Scopus subject areas

  • Analytical Chemistry

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