Trends of drug resistant Mycobacterium tuberculosis in a tertiary tuberculosis center in Iran

Mehdi Mirsaeidi, Payam Tabarsi, Parissa Farnia, Golnaz Ebrahimi, Matthew W. Morris, Mohammad R. Masjedi, Ali A. Velayati, Davood Mansouri

Research output: Contribution to journalArticle

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Abstract

Objective: To determine the drug resistance pattern to first line antituberculous drugs in National Research Institute of Tuberculosis and Lung Disease and to compare resistant rates with previous studies. Methods: An anterograde cross-sectional study was performed. The study includes all adults with documented pulmonary tuberculosis (TB) that were hospitalized in National Research Institute of Tuberculosis and Lung Disease in Tehran, from June 2003 to September 2004. Demographic characteristic, TB categories, and drug susceptibility test results were recorded. Two previous studies regarding drug susceptibility in Iran were selected as historical controls. Results: One hundred and ninety-six new cases and 68 previously treated patients were enrolled in the study. The strains of 61% of new patients and 21% of previously treated patients were fully sensitive to all drugs. The most common resistance was streptomycin (27%) followed by isoniazid (23%) in new cases. Multiple drug resistant strains were noted in 2.6% (95% CI 0.8% to 5.8%) of new cases versus 56% (95% CI 43% to 68%) in previously treated group. The frequency of primary drug resistance to isoniazid was 9.8%-15% or streptomycin 9.8%-13% in the previous studies (p

Original languageEnglish (US)
Pages (from-to)544-550
Number of pages7
JournalSaudi Medical Journal
Volume28
Issue number4
StatePublished - Apr 2007
Externally publishedYes

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Multidrug-Resistant Tuberculosis
Iran
Mycobacterium tuberculosis
Tuberculosis
Pharmaceutical Preparations
Isoniazid
Streptomycin
Drug Resistance
Lung Diseases
Pulmonary Tuberculosis
Cross-Sectional Studies
Demography

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Mirsaeidi, M., Tabarsi, P., Farnia, P., Ebrahimi, G., Morris, M. W., Masjedi, M. R., ... Mansouri, D. (2007). Trends of drug resistant Mycobacterium tuberculosis in a tertiary tuberculosis center in Iran. Saudi Medical Journal, 28(4), 544-550.

Trends of drug resistant Mycobacterium tuberculosis in a tertiary tuberculosis center in Iran. / Mirsaeidi, Mehdi; Tabarsi, Payam; Farnia, Parissa; Ebrahimi, Golnaz; Morris, Matthew W.; Masjedi, Mohammad R.; Velayati, Ali A.; Mansouri, Davood.

In: Saudi Medical Journal, Vol. 28, No. 4, 04.2007, p. 544-550.

Research output: Contribution to journalArticle

Mirsaeidi, M, Tabarsi, P, Farnia, P, Ebrahimi, G, Morris, MW, Masjedi, MR, Velayati, AA & Mansouri, D 2007, 'Trends of drug resistant Mycobacterium tuberculosis in a tertiary tuberculosis center in Iran', Saudi Medical Journal, vol. 28, no. 4, pp. 544-550.
Mirsaeidi M, Tabarsi P, Farnia P, Ebrahimi G, Morris MW, Masjedi MR et al. Trends of drug resistant Mycobacterium tuberculosis in a tertiary tuberculosis center in Iran. Saudi Medical Journal. 2007 Apr;28(4):544-550.
Mirsaeidi, Mehdi ; Tabarsi, Payam ; Farnia, Parissa ; Ebrahimi, Golnaz ; Morris, Matthew W. ; Masjedi, Mohammad R. ; Velayati, Ali A. ; Mansouri, Davood. / Trends of drug resistant Mycobacterium tuberculosis in a tertiary tuberculosis center in Iran. In: Saudi Medical Journal. 2007 ; Vol. 28, No. 4. pp. 544-550.
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