Treatments for Thrombotic Thrombocytopenic Purpura: Plasma, Vincristine, Hemodialysis and Exchange Transfusions

R. L. Hanzlick, N. T. Shah, D. A. Senhauser, John Byrnes, Mohan Khurana, Neil Abramson, Ennio C. Rossi, Francesco Del Greco

Research output: Contribution to journalLetter

30 Citations (Scopus)

Abstract

To the Editor: Byrnes and Khurana1 conclude that, in a case of thrombotic thrombocytopenic purpura, remission was achieved by replacement of a deficient, “plasma factor” by transfusion of exogenous plasma. However, they do not convincingly exclude the possibility that the deficient factor was associated with platelets rather than plasma. The data presented on their patient indicate that the first seven successful exchange transfusions were done with fresh whole blood, which include normal fresh platelets. The patient improved, and despite receiving platelets, thrombotic tendencies were not aggravated. Furthermore, the interval between successive relapses varied from five to 11 days, a period.

Original languageEnglish (US)
Pages (from-to)971-972
Number of pages2
JournalNew England Journal of Medicine
Volume298
Issue number17
DOIs
StatePublished - Apr 27 1978

Fingerprint

Thrombotic Thrombocytopenic Purpura
Vincristine
Renal Dialysis
Blood Platelets
Therapeutics
Recurrence

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Treatments for Thrombotic Thrombocytopenic Purpura : Plasma, Vincristine, Hemodialysis and Exchange Transfusions. / Hanzlick, R. L.; Shah, N. T.; Senhauser, D. A.; Byrnes, John; Khurana, Mohan; Abramson, Neil; Rossi, Ennio C.; Del Greco, Francesco.

In: New England Journal of Medicine, Vol. 298, No. 17, 27.04.1978, p. 971-972.

Research output: Contribution to journalLetter

Hanzlick, RL, Shah, NT, Senhauser, DA, Byrnes, J, Khurana, M, Abramson, N, Rossi, EC & Del Greco, F 1978, 'Treatments for Thrombotic Thrombocytopenic Purpura: Plasma, Vincristine, Hemodialysis and Exchange Transfusions', New England Journal of Medicine, vol. 298, no. 17, pp. 971-972. https://doi.org/10.1056/NEJM197804272981715
Hanzlick, R. L. ; Shah, N. T. ; Senhauser, D. A. ; Byrnes, John ; Khurana, Mohan ; Abramson, Neil ; Rossi, Ennio C. ; Del Greco, Francesco. / Treatments for Thrombotic Thrombocytopenic Purpura : Plasma, Vincristine, Hemodialysis and Exchange Transfusions. In: New England Journal of Medicine. 1978 ; Vol. 298, No. 17. pp. 971-972.
@article{c142770ff221489aa953c84cf43f70db,
title = "Treatments for Thrombotic Thrombocytopenic Purpura: Plasma, Vincristine, Hemodialysis and Exchange Transfusions",
abstract = "To the Editor: Byrnes and Khurana1 conclude that, in a case of thrombotic thrombocytopenic purpura, remission was achieved by replacement of a deficient, “plasma factor” by transfusion of exogenous plasma. However, they do not convincingly exclude the possibility that the deficient factor was associated with platelets rather than plasma. The data presented on their patient indicate that the first seven successful exchange transfusions were done with fresh whole blood, which include normal fresh platelets. The patient improved, and despite receiving platelets, thrombotic tendencies were not aggravated. Furthermore, the interval between successive relapses varied from five to 11 days, a period.",
author = "Hanzlick, {R. L.} and Shah, {N. T.} and Senhauser, {D. A.} and John Byrnes and Mohan Khurana and Neil Abramson and Rossi, {Ennio C.} and {Del Greco}, Francesco",
year = "1978",
month = "4",
day = "27",
doi = "10.1056/NEJM197804272981715",
language = "English (US)",
volume = "298",
pages = "971--972",
journal = "New England Journal of Medicine",
issn = "0028-4793",
publisher = "Massachussetts Medical Society",
number = "17",

}

TY - JOUR

T1 - Treatments for Thrombotic Thrombocytopenic Purpura

T2 - Plasma, Vincristine, Hemodialysis and Exchange Transfusions

AU - Hanzlick, R. L.

AU - Shah, N. T.

AU - Senhauser, D. A.

AU - Byrnes, John

AU - Khurana, Mohan

AU - Abramson, Neil

AU - Rossi, Ennio C.

AU - Del Greco, Francesco

PY - 1978/4/27

Y1 - 1978/4/27

N2 - To the Editor: Byrnes and Khurana1 conclude that, in a case of thrombotic thrombocytopenic purpura, remission was achieved by replacement of a deficient, “plasma factor” by transfusion of exogenous plasma. However, they do not convincingly exclude the possibility that the deficient factor was associated with platelets rather than plasma. The data presented on their patient indicate that the first seven successful exchange transfusions were done with fresh whole blood, which include normal fresh platelets. The patient improved, and despite receiving platelets, thrombotic tendencies were not aggravated. Furthermore, the interval between successive relapses varied from five to 11 days, a period.

AB - To the Editor: Byrnes and Khurana1 conclude that, in a case of thrombotic thrombocytopenic purpura, remission was achieved by replacement of a deficient, “plasma factor” by transfusion of exogenous plasma. However, they do not convincingly exclude the possibility that the deficient factor was associated with platelets rather than plasma. The data presented on their patient indicate that the first seven successful exchange transfusions were done with fresh whole blood, which include normal fresh platelets. The patient improved, and despite receiving platelets, thrombotic tendencies were not aggravated. Furthermore, the interval between successive relapses varied from five to 11 days, a period.

UR - http://www.scopus.com/inward/record.url?scp=0017801417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017801417&partnerID=8YFLogxK

U2 - 10.1056/NEJM197804272981715

DO - 10.1056/NEJM197804272981715

M3 - Letter

C2 - 565463

AN - SCOPUS:0017801417

VL - 298

SP - 971

EP - 972

JO - New England Journal of Medicine

JF - New England Journal of Medicine

SN - 0028-4793

IS - 17

ER -