Treatment with the selective serotonin reuptake inhibitor, fluoxetine, attenuates the fish hypoxia response

Jennifer M. Panlilio, Sara Marin, Marissa B. Lobl, M. Danielle McDonald

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


The selective serotonin reuptake inhibitor (SSRI) fluoxetine (FLX), the active ingredient of the antidepressant drug Prozac, inhibits reuptake of the neurotransmitter, serotonin (5-HT; 5-hydroxytryptamine), into cells by the 5-HT transporter (SERT). Given the role of 5-HT in oxygen detection and the cardiovascular and ventilatory responses of fish to hypoxia, we hypothesized that treatment of the Gulf toadfish, Opsanus beta, with FLX would interfere with their response to hypoxia. Toadfish treated intra-arterially with 3.4 μg.g â '1 FLX under normoxic conditions displayed a transient tachycardia and a biphasic caudal arterial blood pressure (P CA) response that are in direct conflict with the typical hypoxia response. Fish injected intraperitoneally with FLX under normoxia had resting cardiovascular and ventilatory parameters similar to controls. Upon exposure to hypoxia, control toadfish exhibit a significant bradycardia, reduction in P CA and an increase in ventilatory amplitude (V AMP) without any changes in ventilatory frequency (fV). Fish treated IP with 10 μg.g â '1 FLX showed an interference in the cardiovascular and ventilatory response to hypoxia. Interestingly, when treated with 25 μg.g â '1 FLX, the bradycardia and V AMP response to hypoxia were similar to control fish while the P CA response to hypoxia was further inhibited. These results suggest that SERT inhibition by FLX may hinder survival in hypoxia.

Original languageEnglish (US)
Article number31148
JournalScientific reports
StatePublished - Aug 8 2016

ASJC Scopus subject areas

  • General


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