Treatment with imuvert/JV-acetylcysteine protects rats from cyclophosphamide/ cytarabine-induced alopecia: Original article

Joaquin J Jimenez, Hui Sheng Huang, Adel A Yunis

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Abstract

Chemotherapy-induced alopecia is a distressing problem to the cancer patient for which currently there is no effective preventive measure. Recently hnuVert, a biologic response modifier, has been shown to protect from cytarabine-induced alopecia in the young rat model, but not from alopecia induced by cyclophosphamide. In the present study, the rat model was used to examine the effect of N-acetylcysteine on the course of alopecia from cyclophosphamide and of ImuVert plus N-acetylcysteine on alopecia induced by cytarabine-cyclophosphamide combination. The following observations were made: (1) Cyclophosphamide-induced alopecia could be effectively prevented by N-acetylcysteine, administeredparenterally or applied topically in liposomes. (2) Alopecia caused by the combination of cyclophosphamide and cytarabine could be prevented by the parenteral or topical administration of ImuVert plus N-acetylcysteine. The potential applicability of these observations to the clinical setting remains to be determined.

Original languageEnglish
Pages (from-to)271-276
Number of pages6
JournalCancer Investigation
Volume10
Issue number4
DOIs
StatePublished - Jan 1 1992

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ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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