Treatment with calcitonin suppresses the responses of bone, cartilage, and synovium in the early stages of canine experimental osteoarthritis and significantly reduces the severity of the cartilage lesions

Daniel Henri Manicourt, Roy D Altman, James M. Williams, Jean Pierre Devogelaer, Anne Druetz Van Egeren, Mary Ellen Lenz, Daniel Pietryla, Eugene J M A Thonar

Research output: Contribution to journalArticle

109 Citations (Scopus)

Abstract

Objective, To relate the rate of bone resorption to serum levels of both hyaluronan (HA) and antigenic keratan sulfate (KS) in canine experimental osteoarthritis (OA) and to evaluate the effects of calcitonin on these parameters and the OA lesions of the unstable knee. Methods. Twenty-two dogs underwent anterior cruciate ligament transection (ACLT) and 6 dogs underwent sham operation. Urinary pyridinium crosslinks were quantified by high- performance liquid chromatography. Immunoassays quantified hyaluronan (HA) and antigenic KS. Macroscopic and histologic OA lesions were scored. Calcitonin treatment was started on day 14 postsurgery and stopped on either day 49 or day 104 postsurgery. Control dogs and all treated dogs were killed on day 105. Results. All ACLT joints developed OA. In contrast to sham- operated animals, all operated dogs exhibited an early and sustained rise in the levels of their urinary and serum markers. Calcitonin markedly reduced the levels of these markers and the severity of OA lesions. Furthermore, the longer the period of calcitonin therapy, the lower the score of the OA lesions. Conclusion. Bone, synovium, and articular cartilage all appear to be involved in the state of hypermetabolism that develops in unstable joints. Furthermore, the rate of bone resorption increases markedly in the early stages of this OA model and is likely to contribute to cartilage hreakdown. Since calcitonin reduced the severity of OA changes, this form of therapy may have benefits for humans who have recently experienced a traumatic knee injury.

Original languageEnglish (US)
Pages (from-to)1159-1167
Number of pages9
JournalArthritis and Rheumatism
Volume42
Issue number6
DOIs
StatePublished - Jun 1999

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Synovial Membrane
Calcitonin
Osteoarthritis
Cartilage
Canidae
Bone and Bones
Dogs
Keratan Sulfate
Anterior Cruciate Ligament
Hyaluronic Acid
Bone Resorption
Joints
Knee Injuries
Articular Cartilage
Immunoassay
Knee
Biomarkers
High Pressure Liquid Chromatography
Therapeutics
Serum

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

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Treatment with calcitonin suppresses the responses of bone, cartilage, and synovium in the early stages of canine experimental osteoarthritis and significantly reduces the severity of the cartilage lesions. / Manicourt, Daniel Henri; Altman, Roy D; Williams, James M.; Devogelaer, Jean Pierre; Egeren, Anne Druetz Van; Lenz, Mary Ellen; Pietryla, Daniel; Thonar, Eugene J M A.

In: Arthritis and Rheumatism, Vol. 42, No. 6, 06.1999, p. 1159-1167.

Research output: Contribution to journalArticle

Manicourt, Daniel Henri ; Altman, Roy D ; Williams, James M. ; Devogelaer, Jean Pierre ; Egeren, Anne Druetz Van ; Lenz, Mary Ellen ; Pietryla, Daniel ; Thonar, Eugene J M A. / Treatment with calcitonin suppresses the responses of bone, cartilage, and synovium in the early stages of canine experimental osteoarthritis and significantly reduces the severity of the cartilage lesions. In: Arthritis and Rheumatism. 1999 ; Vol. 42, No. 6. pp. 1159-1167.
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abstract = "Objective, To relate the rate of bone resorption to serum levels of both hyaluronan (HA) and antigenic keratan sulfate (KS) in canine experimental osteoarthritis (OA) and to evaluate the effects of calcitonin on these parameters and the OA lesions of the unstable knee. Methods. Twenty-two dogs underwent anterior cruciate ligament transection (ACLT) and 6 dogs underwent sham operation. Urinary pyridinium crosslinks were quantified by high- performance liquid chromatography. Immunoassays quantified hyaluronan (HA) and antigenic KS. Macroscopic and histologic OA lesions were scored. Calcitonin treatment was started on day 14 postsurgery and stopped on either day 49 or day 104 postsurgery. Control dogs and all treated dogs were killed on day 105. Results. All ACLT joints developed OA. In contrast to sham- operated animals, all operated dogs exhibited an early and sustained rise in the levels of their urinary and serum markers. Calcitonin markedly reduced the levels of these markers and the severity of OA lesions. Furthermore, the longer the period of calcitonin therapy, the lower the score of the OA lesions. Conclusion. Bone, synovium, and articular cartilage all appear to be involved in the state of hypermetabolism that develops in unstable joints. Furthermore, the rate of bone resorption increases markedly in the early stages of this OA model and is likely to contribute to cartilage hreakdown. Since calcitonin reduced the severity of OA changes, this form of therapy may have benefits for humans who have recently experienced a traumatic knee injury.",
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AU - Williams, James M.

AU - Devogelaer, Jean Pierre

AU - Egeren, Anne Druetz Van

AU - Lenz, Mary Ellen

AU - Pietryla, Daniel

AU - Thonar, Eugene J M A

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