Treatment resistance and other complicating factors in the management of schizophrenia

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Treatment resistance, along with its sibling partial response, remains a common phenomenon in schizophrenia, complicating the disability burden inherent in the disease. Antipsychotic medications are the mainstay of treatment, and treatment resistance has mainly been defined in terms of poor response to antipsychotic medication. At the same time, clozapine, the most effective antipsychotic, remains underutilized at the expense of exposing patients to polypharmacy. We review known causes of disability in schizophrenia, how they impact various areas of everyday functioning, and discuss potential treatment options including but not limited to pharmacological approaches aimed at maximizing treatment response and reducing treatment resistance.

Original languageEnglish (US)
JournalCNS Spectrums
Volume19
DOIs
StatePublished - Dec 1 2014

Keywords

  • Chronic
  • cognition
  • health
  • refractory
  • schizophrenia

ASJC Scopus subject areas

  • Medicine(all)

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