Treatment of visual loss in pseudotumor cerebri associated with uremia

John Guy, P. K. Johnston, J. J. Corbett, A. L. Day, J. S. Glaser

Research output: Contribution to journalArticle

53 Citations (Scopus)

Abstract

Ten patients with pseudotumor cerebri associated with renal insufficiency had papilledema and elevated intracranial pressure, but neurologic examinations and CT were normal. The 40% frequency of severe visual loss, 20/100 or worse, was higher than expected for pseudotumor cerebri. While furosemide was effective in 3 patients with renal transplants, administration of corticosteroids to 2 other patients did not halt progressive loss of vision. The visual function of 2 patients deteriorated even after lumboperitoneal shunting. Five patients underwent fenestration of the optic nerve sheath. This procedure improved the visual acuity of 3 patients and stabilized vision in the others. While the pathogenesis of pseudotumor cerebri in renal insufficiency is unknown, optic nerve sheath fenestration is the surgical treatment of choice for visual loss unresponsive to medical therapy.

Original languageEnglish
Pages (from-to)28-32
Number of pages5
JournalNeurology
Volume40
Issue number1
StatePublished - Jan 1 1990

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Pseudotumor Cerebri
Uremia
Optic Nerve
Renal Insufficiency
Therapeutics
Papilledema
Intracranial Hypertension
Furosemide
Neurologic Examination
Visual Acuity
Adrenal Cortex Hormones
Transplants
Kidney

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Guy, J., Johnston, P. K., Corbett, J. J., Day, A. L., & Glaser, J. S. (1990). Treatment of visual loss in pseudotumor cerebri associated with uremia. Neurology, 40(1), 28-32.

Treatment of visual loss in pseudotumor cerebri associated with uremia. / Guy, John; Johnston, P. K.; Corbett, J. J.; Day, A. L.; Glaser, J. S.

In: Neurology, Vol. 40, No. 1, 01.01.1990, p. 28-32.

Research output: Contribution to journalArticle

Guy, J, Johnston, PK, Corbett, JJ, Day, AL & Glaser, JS 1990, 'Treatment of visual loss in pseudotumor cerebri associated with uremia', Neurology, vol. 40, no. 1, pp. 28-32.
Guy J, Johnston PK, Corbett JJ, Day AL, Glaser JS. Treatment of visual loss in pseudotumor cerebri associated with uremia. Neurology. 1990 Jan 1;40(1):28-32.
Guy, John ; Johnston, P. K. ; Corbett, J. J. ; Day, A. L. ; Glaser, J. S. / Treatment of visual loss in pseudotumor cerebri associated with uremia. In: Neurology. 1990 ; Vol. 40, No. 1. pp. 28-32.
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