Treatment of visual loss in pseudotumor cerebri associated with uremia

J. Guy, P. K. Johnston, J. J. Corbett, A. L. Day, J. S. Glaser

Research output: Contribution to journalArticlepeer-review

55 Scopus citations


Ten patients with pseudotumor cerebri associated with renal insufficiency had papilledema and elevated intracranial pressure, but neurologic examinations and CT were normal. The 40% frequency of severe visual loss, 20/100 or worse, was higher than expected for pseudotumor cerebri. While furosemide was effective in 3 patients with renal transplants, administration of corticosteroids to 2 other patients did not halt progressive loss of vision. The visual function of 2 patients deteriorated even after lumboperitoneal shunting. Five patients underwent fenestration of the optic nerve sheath. This procedure improved the visual acuity of 3 patients and stabilized vision in the others. While the pathogenesis of pseudotumor cerebri in renal insufficiency is unknown, optic nerve sheath fenestration is the surgical treatment of choice for visual loss unresponsive to medical therapy.

Original languageEnglish (US)
Pages (from-to)28-32
Number of pages5
Issue number1
StatePublished - Jan 1990

ASJC Scopus subject areas

  • Clinical Neurology


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