TY - JOUR
T1 - Treatment of Thrombotic Thrombocytopenic Purpura with Plasma
AU - Byrnes, John J.
AU - Khurana, Mohan
PY - 1977/12/22
Y1 - 1977/12/22
N2 - Thrombotic thrombocytopenic purpura, the acute form of which is usually fatal, is characterized clinically by thrombocytopenia, microangiopathic hemolytic anemia, fluctuating neurologic signs and renal dysfunction, and pathologically by diffuse thrombotic occlusions in the microcirculation, in which platelets are consumed. In the patient described in thi report, antiplatelet agents and glucocorticoids were tried but produced no clear benefit. She received repeated but transient relief from exchange transfusions and also brief improvement from splenectomy. Exchange transfusions were then shown to be effective because they provided a missing plasma factor. Infusion of large quantities of plasma effectively controlled the disease until a sustained remission ensued. It was concluded that the pathogenesis of thrombotic thrombocytopenic purpura in this patient involved a deficiency of plasma factor.
AB - Thrombotic thrombocytopenic purpura, the acute form of which is usually fatal, is characterized clinically by thrombocytopenia, microangiopathic hemolytic anemia, fluctuating neurologic signs and renal dysfunction, and pathologically by diffuse thrombotic occlusions in the microcirculation, in which platelets are consumed. In the patient described in thi report, antiplatelet agents and glucocorticoids were tried but produced no clear benefit. She received repeated but transient relief from exchange transfusions and also brief improvement from splenectomy. Exchange transfusions were then shown to be effective because they provided a missing plasma factor. Infusion of large quantities of plasma effectively controlled the disease until a sustained remission ensued. It was concluded that the pathogenesis of thrombotic thrombocytopenic purpura in this patient involved a deficiency of plasma factor.
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U2 - 10.1056/NEJM197712222972507
DO - 10.1056/NEJM197712222972507
M3 - Article
C2 - 562982
AN - SCOPUS:0017588199
VL - 297
SP - 1386
EP - 1389
JO - New England Journal of Medicine
JF - New England Journal of Medicine
SN - 0028-4793
IS - 25
ER -