Treatment of Strongyloides stercoralis hyperinfection-associated septic shock and acute respiratory distress syndrome with drotrecogin alfa (activated) in a renal transplant recipient

J. M. Huston, S. R. Eachempati, J. R. Rodney, C. Cayci, D. Fusco, M. Mathew, J. Shou, Michael Goldstein, S. Kapur, P. S. Barie

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

We report a case of Strongyloides stercoralis hyperinfection syndrome in a renal transplant recipient complicated by septic shock, acute respiratory distress syndrome, and Klebsiella pneumoniae superinfection. The patient was treated successfully with drotrecogin alfa (activated), parenteral ivermectin, albendazole, and piperacillin/tazobactam. This outcome suggests that drotrecogin alfa (activated) may be useful therapy for transplant recipients who develop severe sepsis or septic shock secondary to potentially lethal opportunistic infections.

Original languageEnglish (US)
Pages (from-to)277-280
Number of pages4
JournalTransplant Infectious Disease
Volume11
Issue number3
DOIs
StatePublished - Jun 2009
Externally publishedYes

Fingerprint

Strongyloides stercoralis
Adult Respiratory Distress Syndrome
Septic Shock
Kidney
Albendazole
Ivermectin
Superinfection
Opportunistic Infections
Klebsiella pneumoniae
Sepsis
Therapeutics
drotrecogin alfa activated
Transplant Recipients
tazobactam drug combination piperacillin

Keywords

  • Drotrecogin alfa (activated)
  • Ivermectin
  • Renal transplantation
  • Severe sepsis
  • Strongyloides stercoralis

ASJC Scopus subject areas

  • Transplantation
  • Infectious Diseases

Cite this

Treatment of Strongyloides stercoralis hyperinfection-associated septic shock and acute respiratory distress syndrome with drotrecogin alfa (activated) in a renal transplant recipient. / Huston, J. M.; Eachempati, S. R.; Rodney, J. R.; Cayci, C.; Fusco, D.; Mathew, M.; Shou, J.; Goldstein, Michael; Kapur, S.; Barie, P. S.

In: Transplant Infectious Disease, Vol. 11, No. 3, 06.2009, p. 277-280.

Research output: Contribution to journalArticle

Huston, J. M. ; Eachempati, S. R. ; Rodney, J. R. ; Cayci, C. ; Fusco, D. ; Mathew, M. ; Shou, J. ; Goldstein, Michael ; Kapur, S. ; Barie, P. S. / Treatment of Strongyloides stercoralis hyperinfection-associated septic shock and acute respiratory distress syndrome with drotrecogin alfa (activated) in a renal transplant recipient. In: Transplant Infectious Disease. 2009 ; Vol. 11, No. 3. pp. 277-280.
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AU - Fusco, D.

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