Treatment of sleep-disordered breathing in children with myelomeningocele

Valerie G. Kirk, Angela Morielli, David Gozal, Carole L. Marcus, Karen A. Waters, Lynn A. D'Andrea, Carol L. Rosen, Marcel J. Deray, Robert T. Brouillette

Research output: Contribution to journalArticle

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Abstract

The prevalence of moderate to severe sleep-disordered breathing (SDB) in patients with myelomeningocele may be as high as 20%, but little information is available regarding treatment of these patients. To assess the efficacy and complications of treatments for these children, we collected data on 73 patients from seven pediatric sleep laboratories. Obstructive sleep apnea (OSA, n = 30) and central apnea (n = 25) occurred more frequently than central hypoventilation (n = 12). We also describe a sleep-exacerbated restrictive lung disease type of SDB in 6 patients who had hypoxemia during sleep without apnea or central hypoventilation. For each type of SDB, effective treatments were identified in a stepwise process, moving towards more complex and invasive therapies. For OSA, adenotonsillectomy was often ineffective (10/14), whereas nasal continuous positive airway pressure (CPAP) was usually successful (18/21). For central apnea, methylxanthines and/or supplemental oxygen proved sufficient in 2 of 9 and 3 of 6, respectively, but noninvasive positive pressure ventilation was required in 7 children. For central hypoventilation, supplemental oxygen (alone or with methylxanthines), noninvasive positive pressure ventilation, and tracheostomy with positive pressure ventilation were effective in 3, 2, and 2 patients, respectively. Sleep-exacerbated restrictive lung disease always required supplemental oxygen treatment, but in 2 cases also required noninvasive positive pressure ventilation; nutritional and orthopedic procedures also were helpful. Posterior fosse decompression was used for the first three types of SDB, but data were insufficient to delineate specific recommendations for or against its use. In summary, evaluation by an experienced, multidisciplinary team can establish an effective treatment regime for a child with myelomeningocele and SDB. (C) 2000 Wiley-Liss, Inc.

Original languageEnglish
Pages (from-to)445-452
Number of pages8
JournalPediatric Pulmonology
Volume30
Issue number6
DOIs
StatePublished - Dec 19 2000

Fingerprint

Meningomyelocele
Sleep Apnea Syndromes
Positive-Pressure Respiration
Hypoventilation
Central Sleep Apnea
Sleep
Oxygen
Lung Diseases
Therapeutics
Orthopedic Procedures
Continuous Positive Airway Pressure
Tracheostomy
Obstructive Sleep Apnea
Decompression
Pediatrics

Keywords

  • Central hypoventilation syndrome
  • Children
  • Myelomeningocele
  • Pulmonary function
  • Sleep apnea syndromes
  • Sleep-disordered breathing
  • Treatment

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Kirk, V. G., Morielli, A., Gozal, D., Marcus, C. L., Waters, K. A., D'Andrea, L. A., ... Brouillette, R. T. (2000). Treatment of sleep-disordered breathing in children with myelomeningocele. Pediatric Pulmonology, 30(6), 445-452. https://doi.org/10.1002/1099-0496(200012)30:6<445::AID-PPUL2>3.0.CO;2-C

Treatment of sleep-disordered breathing in children with myelomeningocele. / Kirk, Valerie G.; Morielli, Angela; Gozal, David; Marcus, Carole L.; Waters, Karen A.; D'Andrea, Lynn A.; Rosen, Carol L.; Deray, Marcel J.; Brouillette, Robert T.

In: Pediatric Pulmonology, Vol. 30, No. 6, 19.12.2000, p. 445-452.

Research output: Contribution to journalArticle

Kirk, VG, Morielli, A, Gozal, D, Marcus, CL, Waters, KA, D'Andrea, LA, Rosen, CL, Deray, MJ & Brouillette, RT 2000, 'Treatment of sleep-disordered breathing in children with myelomeningocele', Pediatric Pulmonology, vol. 30, no. 6, pp. 445-452. https://doi.org/10.1002/1099-0496(200012)30:6<445::AID-PPUL2>3.0.CO;2-C
Kirk, Valerie G. ; Morielli, Angela ; Gozal, David ; Marcus, Carole L. ; Waters, Karen A. ; D'Andrea, Lynn A. ; Rosen, Carol L. ; Deray, Marcel J. ; Brouillette, Robert T. / Treatment of sleep-disordered breathing in children with myelomeningocele. In: Pediatric Pulmonology. 2000 ; Vol. 30, No. 6. pp. 445-452.
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