Treatment of retinal detachment with an encircling band and buckle implant: A comparative pilot study between poly (styrene-b-isobutylene-b-styrene) (SIBS) and trimethyl terminated polydimethylsiloxane (PDMS)

Mariela Aguilar, Hideo Yamamoto, Edgar Espana, Ana Carolina Acosta, Marcia Orozco, Mohamed Aly, Esdras Arrieta, Eleut Hernandez, John Martin, Sander Dubovy, William Smiddy, Leonard Pinchuk, Jean Marie Parel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Purpose: To demonstrate the biocompatibility of SIBS implants as compared to PDMS implants in the treatment of retinal detachment in New Zealand White (NZW) rabbit model.1-2 Introduction: Scierai encircling bands, fixation rings and buckles are utilized for closure of retinal breaks and retina reattachment. The PDA approved PDMS-implant is associated with several post-operative complications, involving thick-fibrotic encapsulations. SIBS, an elastomeric triblock copolymer, was recently PDA approved for use in a cardiovascular drug eluting stent (TAXUS™, Boston Scientific Corp., MA) and showed excellent biocompatibility and slow drug release capability. Materials and Methods: SIBS (9-mol%-styrene) implants were fabricated (InnFocus LLC, USA) to match PDMS implants (Labtician, Inc, Canada) dimensions. 5 NZW rabbits received SIBS and 4, PDMS-implants. Post-operative exam sequence: day 1 and 2, week 1, 2, 3, 4 and 6, and monthly thereafter for up to 1 year. Anatomohistopathology exams sequence: one SIBS animal at 6 weeks and one animal of each treatment group at 3 and 6-months, and two at 12-months. Results: SIBS compared to PDMS animals exhibited less inflammation and a better buckling effect during the first 6 weeks. At POD 9 months, the conjunctival injection in the SIBS rabbit was none as opposed to the PDMS value and the buckling effect for both groups were equal. There were no visible signs of encapsulation with SIBS. There were no infections in the 9 animals and none of the implants extruded thus far (<10 months). Conclusion: SIBS encircling bands, sleeves, and buckle implants are well tolerated in the rabbit model.

Original languageEnglish (US)
Title of host publicationOphthalmic Technologies XVI
DOIs
StatePublished - Jun 30 2006
EventOphthalmic Technologies XVI - San Jose, CA, United States
Duration: Jan 21 2006Jan 24 2006

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6138
ISSN (Print)1605-7422

Other

OtherOphthalmic Technologies XVI
CountryUnited States
CitySan Jose, CA
Period1/21/061/24/06

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Keywords

  • Buckle
  • Fixation ring
  • PDMS
  • Poly (styrene-b-isobutylene-b-styrene)
  • Retinal break
  • Retinal detachment
  • Scleral encircling bands
  • SIBS
  • Sleeve
  • Trimethyl terminated Polydimethylsiloxane

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Aguilar, M., Yamamoto, H., Espana, E., Acosta, A. C., Orozco, M., Aly, M., Arrieta, E., Hernandez, E., Martin, J., Dubovy, S., Smiddy, W., Pinchuk, L., & Parel, J. M. (2006). Treatment of retinal detachment with an encircling band and buckle implant: A comparative pilot study between poly (styrene-b-isobutylene-b-styrene) (SIBS) and trimethyl terminated polydimethylsiloxane (PDMS). In Ophthalmic Technologies XVI [61381S] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 6138). https://doi.org/10.1117/12.661174