Abstract
Purpose: To demonstrate the biocompatibility of SIBS implants as compared to PDMS implants in the treatment of retinal detachment in New Zealand White (NZW) rabbit model.1-2 Introduction: Scierai encircling bands, fixation rings and buckles are utilized for closure of retinal breaks and retina reattachment. The PDA approved PDMS-implant is associated with several post-operative complications, involving thick-fibrotic encapsulations. SIBS, an elastomeric triblock copolymer, was recently PDA approved for use in a cardiovascular drug eluting stent (TAXUS™, Boston Scientific Corp., MA) and showed excellent biocompatibility and slow drug release capability. Materials and Methods: SIBS (9-mol%-styrene) implants were fabricated (InnFocus LLC, USA) to match PDMS implants (Labtician, Inc, Canada) dimensions. 5 NZW rabbits received SIBS and 4, PDMS-implants. Post-operative exam sequence: day 1 and 2, week 1, 2, 3, 4 and 6, and monthly thereafter for up to 1 year. Anatomohistopathology exams sequence: one SIBS animal at 6 weeks and one animal of each treatment group at 3 and 6-months, and two at 12-months. Results: SIBS compared to PDMS animals exhibited less inflammation and a better buckling effect during the first 6 weeks. At POD 9 months, the conjunctival injection in the SIBS rabbit was none as opposed to the PDMS value and the buckling effect for both groups were equal. There were no visible signs of encapsulation with SIBS. There were no infections in the 9 animals and none of the implants extruded thus far (<10 months). Conclusion: SIBS encircling bands, sleeves, and buckle implants are well tolerated in the rabbit model.
| Original language | English |
|---|---|
| Title of host publication | Progress in Biomedical Optics and Imaging - Proceedings of SPIE |
| Volume | 6138 |
| DOIs | |
| State | Published - Jun 30 2006 |
| Event | Ophthalmic Technologies XVI - San Jose, CA, United States Duration: Jan 21 2006 → Jan 24 2006 |
Other
| Other | Ophthalmic Technologies XVI |
|---|---|
| Country | United States |
| City | San Jose, CA |
| Period | 1/21/06 → 1/24/06 |
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Keywords
- Buckle
- Fixation ring
- PDMS
- Poly (styrene-b-isobutylene-b-styrene)
- Retinal break
- Retinal detachment
- Scleral encircling bands
- SIBS
- Sleeve
- Trimethyl terminated Polydimethylsiloxane
ASJC Scopus subject areas
- Engineering(all)
Cite this
Treatment of retinal detachment with an encircling band and buckle implant : A comparative pilot study between poly (styrene-b-isobutylene-b-styrene) (SIBS) and trimethyl terminated polydimethylsiloxane (PDMS). / Aguilar, Mariela; Yamamoto, Hideo; Espana, Edgar; Acosta, Ana Carolina; Orozco, Marcia; Aly, Mohamed; Arrieta Quintero, Esdras; Hernandez, Eleut; Martin, John; Dubovy, Sander; Smiddy, William E; Pinchuk, Leonard; Parel, Jean-Marie A.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6138 2006. 61381S.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - Treatment of retinal detachment with an encircling band and buckle implant
T2 - A comparative pilot study between poly (styrene-b-isobutylene-b-styrene) (SIBS) and trimethyl terminated polydimethylsiloxane (PDMS)
AU - Aguilar, Mariela
AU - Yamamoto, Hideo
AU - Espana, Edgar
AU - Acosta, Ana Carolina
AU - Orozco, Marcia
AU - Aly, Mohamed
AU - Arrieta Quintero, Esdras
AU - Hernandez, Eleut
AU - Martin, John
AU - Dubovy, Sander
AU - Smiddy, William E
AU - Pinchuk, Leonard
AU - Parel, Jean-Marie A
PY - 2006/6/30
Y1 - 2006/6/30
N2 - Purpose: To demonstrate the biocompatibility of SIBS implants as compared to PDMS implants in the treatment of retinal detachment in New Zealand White (NZW) rabbit model.1-2 Introduction: Scierai encircling bands, fixation rings and buckles are utilized for closure of retinal breaks and retina reattachment. The PDA approved PDMS-implant is associated with several post-operative complications, involving thick-fibrotic encapsulations. SIBS, an elastomeric triblock copolymer, was recently PDA approved for use in a cardiovascular drug eluting stent (TAXUS™, Boston Scientific Corp., MA) and showed excellent biocompatibility and slow drug release capability. Materials and Methods: SIBS (9-mol%-styrene) implants were fabricated (InnFocus LLC, USA) to match PDMS implants (Labtician, Inc, Canada) dimensions. 5 NZW rabbits received SIBS and 4, PDMS-implants. Post-operative exam sequence: day 1 and 2, week 1, 2, 3, 4 and 6, and monthly thereafter for up to 1 year. Anatomohistopathology exams sequence: one SIBS animal at 6 weeks and one animal of each treatment group at 3 and 6-months, and two at 12-months. Results: SIBS compared to PDMS animals exhibited less inflammation and a better buckling effect during the first 6 weeks. At POD 9 months, the conjunctival injection in the SIBS rabbit was none as opposed to the PDMS value and the buckling effect for both groups were equal. There were no visible signs of encapsulation with SIBS. There were no infections in the 9 animals and none of the implants extruded thus far (<10 months). Conclusion: SIBS encircling bands, sleeves, and buckle implants are well tolerated in the rabbit model.
AB - Purpose: To demonstrate the biocompatibility of SIBS implants as compared to PDMS implants in the treatment of retinal detachment in New Zealand White (NZW) rabbit model.1-2 Introduction: Scierai encircling bands, fixation rings and buckles are utilized for closure of retinal breaks and retina reattachment. The PDA approved PDMS-implant is associated with several post-operative complications, involving thick-fibrotic encapsulations. SIBS, an elastomeric triblock copolymer, was recently PDA approved for use in a cardiovascular drug eluting stent (TAXUS™, Boston Scientific Corp., MA) and showed excellent biocompatibility and slow drug release capability. Materials and Methods: SIBS (9-mol%-styrene) implants were fabricated (InnFocus LLC, USA) to match PDMS implants (Labtician, Inc, Canada) dimensions. 5 NZW rabbits received SIBS and 4, PDMS-implants. Post-operative exam sequence: day 1 and 2, week 1, 2, 3, 4 and 6, and monthly thereafter for up to 1 year. Anatomohistopathology exams sequence: one SIBS animal at 6 weeks and one animal of each treatment group at 3 and 6-months, and two at 12-months. Results: SIBS compared to PDMS animals exhibited less inflammation and a better buckling effect during the first 6 weeks. At POD 9 months, the conjunctival injection in the SIBS rabbit was none as opposed to the PDMS value and the buckling effect for both groups were equal. There were no visible signs of encapsulation with SIBS. There were no infections in the 9 animals and none of the implants extruded thus far (<10 months). Conclusion: SIBS encircling bands, sleeves, and buckle implants are well tolerated in the rabbit model.
KW - Buckle
KW - Fixation ring
KW - PDMS
KW - Poly (styrene-b-isobutylene-b-styrene)
KW - Retinal break
KW - Retinal detachment
KW - Scleral encircling bands
KW - SIBS
KW - Sleeve
KW - Trimethyl terminated Polydimethylsiloxane
UR - http://www.scopus.com/inward/record.url?scp=33745361225&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33745361225&partnerID=8YFLogxK
U2 - 10.1117/12.661174
DO - 10.1117/12.661174
M3 - Conference contribution
SN - 0819461814
SN - 9780819461810
VL - 6138
BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
ER -