Treatment of retinal detachment with an encircling band and buckle implant

A comparative pilot study between poly (styrene-b-isobutylene-b-styrene) (SIBS) and trimethyl terminated polydimethylsiloxane (PDMS)

Mariela Aguilar, Hideo Yamamoto, Edgar Espana, Ana Carolina Acosta, Marcia Orozco, Mohamed Aly, Esdras Arrieta Quintero, Eleut Hernandez, John Martin, Sander Dubovy, William E Smiddy, Leonard Pinchuk, Jean-Marie A Parel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Purpose: To demonstrate the biocompatibility of SIBS implants as compared to PDMS implants in the treatment of retinal detachment in New Zealand White (NZW) rabbit model.1-2 Introduction: Scierai encircling bands, fixation rings and buckles are utilized for closure of retinal breaks and retina reattachment. The PDA approved PDMS-implant is associated with several post-operative complications, involving thick-fibrotic encapsulations. SIBS, an elastomeric triblock copolymer, was recently PDA approved for use in a cardiovascular drug eluting stent (TAXUS™, Boston Scientific Corp., MA) and showed excellent biocompatibility and slow drug release capability. Materials and Methods: SIBS (9-mol%-styrene) implants were fabricated (InnFocus LLC, USA) to match PDMS implants (Labtician, Inc, Canada) dimensions. 5 NZW rabbits received SIBS and 4, PDMS-implants. Post-operative exam sequence: day 1 and 2, week 1, 2, 3, 4 and 6, and monthly thereafter for up to 1 year. Anatomohistopathology exams sequence: one SIBS animal at 6 weeks and one animal of each treatment group at 3 and 6-months, and two at 12-months. Results: SIBS compared to PDMS animals exhibited less inflammation and a better buckling effect during the first 6 weeks. At POD 9 months, the conjunctival injection in the SIBS rabbit was none as opposed to the PDMS value and the buckling effect for both groups were equal. There were no visible signs of encapsulation with SIBS. There were no infections in the 9 animals and none of the implants extruded thus far (<10 months). Conclusion: SIBS encircling bands, sleeves, and buckle implants are well tolerated in the rabbit model.

Original languageEnglish
Title of host publicationProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume6138
DOIs
StatePublished - Jun 30 2006
EventOphthalmic Technologies XVI - San Jose, CA, United States
Duration: Jan 21 2006Jan 24 2006

Other

OtherOphthalmic Technologies XVI
CountryUnited States
CitySan Jose, CA
Period1/21/061/24/06

Fingerprint

Polydimethylsiloxane
Styrene
Animals
Personal digital assistants
Biocompatibility
Encapsulation
Buckling
Stents

Keywords

  • Buckle
  • Fixation ring
  • PDMS
  • Poly (styrene-b-isobutylene-b-styrene)
  • Retinal break
  • Retinal detachment
  • Scleral encircling bands
  • SIBS
  • Sleeve
  • Trimethyl terminated Polydimethylsiloxane

ASJC Scopus subject areas

  • Engineering(all)

Cite this

Treatment of retinal detachment with an encircling band and buckle implant : A comparative pilot study between poly (styrene-b-isobutylene-b-styrene) (SIBS) and trimethyl terminated polydimethylsiloxane (PDMS). / Aguilar, Mariela; Yamamoto, Hideo; Espana, Edgar; Acosta, Ana Carolina; Orozco, Marcia; Aly, Mohamed; Arrieta Quintero, Esdras; Hernandez, Eleut; Martin, John; Dubovy, Sander; Smiddy, William E; Pinchuk, Leonard; Parel, Jean-Marie A.

Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6138 2006. 61381S.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Aguilar, M, Yamamoto, H, Espana, E, Acosta, AC, Orozco, M, Aly, M, Arrieta Quintero, E, Hernandez, E, Martin, J, Dubovy, S, Smiddy, WE, Pinchuk, L & Parel, J-MA 2006, Treatment of retinal detachment with an encircling band and buckle implant: A comparative pilot study between poly (styrene-b-isobutylene-b-styrene) (SIBS) and trimethyl terminated polydimethylsiloxane (PDMS). in Progress in Biomedical Optics and Imaging - Proceedings of SPIE. vol. 6138, 61381S, Ophthalmic Technologies XVI, San Jose, CA, United States, 1/21/06. https://doi.org/10.1117/12.661174
Aguilar M, Yamamoto H, Espana E, Acosta AC, Orozco M, Aly M et al. Treatment of retinal detachment with an encircling band and buckle implant: A comparative pilot study between poly (styrene-b-isobutylene-b-styrene) (SIBS) and trimethyl terminated polydimethylsiloxane (PDMS). In Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6138. 2006. 61381S https://doi.org/10.1117/12.661174
Aguilar, Mariela ; Yamamoto, Hideo ; Espana, Edgar ; Acosta, Ana Carolina ; Orozco, Marcia ; Aly, Mohamed ; Arrieta Quintero, Esdras ; Hernandez, Eleut ; Martin, John ; Dubovy, Sander ; Smiddy, William E ; Pinchuk, Leonard ; Parel, Jean-Marie A. / Treatment of retinal detachment with an encircling band and buckle implant : A comparative pilot study between poly (styrene-b-isobutylene-b-styrene) (SIBS) and trimethyl terminated polydimethylsiloxane (PDMS). Progress in Biomedical Optics and Imaging - Proceedings of SPIE. Vol. 6138 2006.
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abstract = "Purpose: To demonstrate the biocompatibility of SIBS implants as compared to PDMS implants in the treatment of retinal detachment in New Zealand White (NZW) rabbit model.1-2 Introduction: Scierai encircling bands, fixation rings and buckles are utilized for closure of retinal breaks and retina reattachment. The PDA approved PDMS-implant is associated with several post-operative complications, involving thick-fibrotic encapsulations. SIBS, an elastomeric triblock copolymer, was recently PDA approved for use in a cardiovascular drug eluting stent (TAXUS™, Boston Scientific Corp., MA) and showed excellent biocompatibility and slow drug release capability. Materials and Methods: SIBS (9-mol{\%}-styrene) implants were fabricated (InnFocus LLC, USA) to match PDMS implants (Labtician, Inc, Canada) dimensions. 5 NZW rabbits received SIBS and 4, PDMS-implants. Post-operative exam sequence: day 1 and 2, week 1, 2, 3, 4 and 6, and monthly thereafter for up to 1 year. Anatomohistopathology exams sequence: one SIBS animal at 6 weeks and one animal of each treatment group at 3 and 6-months, and two at 12-months. Results: SIBS compared to PDMS animals exhibited less inflammation and a better buckling effect during the first 6 weeks. At POD 9 months, the conjunctival injection in the SIBS rabbit was none as opposed to the PDMS value and the buckling effect for both groups were equal. There were no visible signs of encapsulation with SIBS. There were no infections in the 9 animals and none of the implants extruded thus far (<10 months). Conclusion: SIBS encircling bands, sleeves, and buckle implants are well tolerated in the rabbit model.",
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T1 - Treatment of retinal detachment with an encircling band and buckle implant

T2 - A comparative pilot study between poly (styrene-b-isobutylene-b-styrene) (SIBS) and trimethyl terminated polydimethylsiloxane (PDMS)

AU - Aguilar, Mariela

AU - Yamamoto, Hideo

AU - Espana, Edgar

AU - Acosta, Ana Carolina

AU - Orozco, Marcia

AU - Aly, Mohamed

AU - Arrieta Quintero, Esdras

AU - Hernandez, Eleut

AU - Martin, John

AU - Dubovy, Sander

AU - Smiddy, William E

AU - Pinchuk, Leonard

AU - Parel, Jean-Marie A

PY - 2006/6/30

Y1 - 2006/6/30

N2 - Purpose: To demonstrate the biocompatibility of SIBS implants as compared to PDMS implants in the treatment of retinal detachment in New Zealand White (NZW) rabbit model.1-2 Introduction: Scierai encircling bands, fixation rings and buckles are utilized for closure of retinal breaks and retina reattachment. The PDA approved PDMS-implant is associated with several post-operative complications, involving thick-fibrotic encapsulations. SIBS, an elastomeric triblock copolymer, was recently PDA approved for use in a cardiovascular drug eluting stent (TAXUS™, Boston Scientific Corp., MA) and showed excellent biocompatibility and slow drug release capability. Materials and Methods: SIBS (9-mol%-styrene) implants were fabricated (InnFocus LLC, USA) to match PDMS implants (Labtician, Inc, Canada) dimensions. 5 NZW rabbits received SIBS and 4, PDMS-implants. Post-operative exam sequence: day 1 and 2, week 1, 2, 3, 4 and 6, and monthly thereafter for up to 1 year. Anatomohistopathology exams sequence: one SIBS animal at 6 weeks and one animal of each treatment group at 3 and 6-months, and two at 12-months. Results: SIBS compared to PDMS animals exhibited less inflammation and a better buckling effect during the first 6 weeks. At POD 9 months, the conjunctival injection in the SIBS rabbit was none as opposed to the PDMS value and the buckling effect for both groups were equal. There were no visible signs of encapsulation with SIBS. There were no infections in the 9 animals and none of the implants extruded thus far (<10 months). Conclusion: SIBS encircling bands, sleeves, and buckle implants are well tolerated in the rabbit model.

AB - Purpose: To demonstrate the biocompatibility of SIBS implants as compared to PDMS implants in the treatment of retinal detachment in New Zealand White (NZW) rabbit model.1-2 Introduction: Scierai encircling bands, fixation rings and buckles are utilized for closure of retinal breaks and retina reattachment. The PDA approved PDMS-implant is associated with several post-operative complications, involving thick-fibrotic encapsulations. SIBS, an elastomeric triblock copolymer, was recently PDA approved for use in a cardiovascular drug eluting stent (TAXUS™, Boston Scientific Corp., MA) and showed excellent biocompatibility and slow drug release capability. Materials and Methods: SIBS (9-mol%-styrene) implants were fabricated (InnFocus LLC, USA) to match PDMS implants (Labtician, Inc, Canada) dimensions. 5 NZW rabbits received SIBS and 4, PDMS-implants. Post-operative exam sequence: day 1 and 2, week 1, 2, 3, 4 and 6, and monthly thereafter for up to 1 year. Anatomohistopathology exams sequence: one SIBS animal at 6 weeks and one animal of each treatment group at 3 and 6-months, and two at 12-months. Results: SIBS compared to PDMS animals exhibited less inflammation and a better buckling effect during the first 6 weeks. At POD 9 months, the conjunctival injection in the SIBS rabbit was none as opposed to the PDMS value and the buckling effect for both groups were equal. There were no visible signs of encapsulation with SIBS. There were no infections in the 9 animals and none of the implants extruded thus far (<10 months). Conclusion: SIBS encircling bands, sleeves, and buckle implants are well tolerated in the rabbit model.

KW - Buckle

KW - Fixation ring

KW - PDMS

KW - Poly (styrene-b-isobutylene-b-styrene)

KW - Retinal break

KW - Retinal detachment

KW - Scleral encircling bands

KW - SIBS

KW - Sleeve

KW - Trimethyl terminated Polydimethylsiloxane

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