Treatment of Paget disease of bone (osteitis deformans). Results of a one year study with sodium etidronate

M. R A Khairi, C. C. Johnston, Roy D Altman, H. N. Wellman, A. N. Serafini, R. R. Sankey

Research output: Contribution to journalArticle

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Abstract

A double blind crossover study was performed, in which 50 symptomatic patients with Paget disease were treated with sodium etidronate doses of 1, 2.5, 5, 10, or 20 mg/kg, or were given placebo. After 6 mth, the patients were reassigned to treatment with placebo or sodium etidronate, 5, 10, or 20 mg/kg. Sodium etidronate in dosages of 5, 10, or 20 mg/kg/day resulted in significant improvement in levels of serum alkaline phosphatase and urinary hydroxyproline, as well as clinical symptoms and bone scans. Bone scans and urinary determinations showed statistically greater improvement with sodium etidronate 20 mg/kg in comparison with patients who received sodium etidronate 5 mg/kg for 12 mth. After withdrawal of effective therapy, 5 of 9 patients continued to have remission of their symptoms with placebo for an additional 6 mth.

Original languageEnglish
Pages (from-to)562-567
Number of pages6
JournalJournal of the American Medical Association
Volume230
Issue number4
DOIs
StatePublished - Dec 1 1974

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Etidronic Acid
Osteitis Deformans
Placebos
Therapeutics
Bone and Bones
Hydroxyproline
Double-Blind Method
Cross-Over Studies
Alkaline Phosphatase
Serum

ASJC Scopus subject areas

  • Medicine(all)

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Treatment of Paget disease of bone (osteitis deformans). Results of a one year study with sodium etidronate. / Khairi, M. R A; Johnston, C. C.; Altman, Roy D; Wellman, H. N.; Serafini, A. N.; Sankey, R. R.

In: Journal of the American Medical Association, Vol. 230, No. 4, 01.12.1974, p. 562-567.

Research output: Contribution to journalArticle

Khairi, M. R A ; Johnston, C. C. ; Altman, Roy D ; Wellman, H. N. ; Serafini, A. N. ; Sankey, R. R. / Treatment of Paget disease of bone (osteitis deformans). Results of a one year study with sodium etidronate. In: Journal of the American Medical Association. 1974 ; Vol. 230, No. 4. pp. 562-567.
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