Treatment of newly diagnosed metastatic prostate cancer patients with chemotherapy agents in combination with hormones versus hormones alone

Gerald P. Murphy, Sunmolu Beckley, Mark F. Brady, T. Ming Chu, Jean B. Dekernion, Chirpriya Dhabuwala, John F. Gaeta, Robert P. Gibbons, Stefan A. Loening, Charles F. McKiel, David G. McLeod, J. Edson Pontes, George R. Prout, Peter T. Scardino, Jorgen U. Schlegel, Joseph D. Schmidt, William W. Scott, Nelson H. Slack, Mark S. Soloway

Research output: Contribution to journalArticlepeer-review

126 Scopus citations


A prospective trial from July 1976 to September 1980 by the National Prostaitc Cancer Project randomized newly diagnosed metastatic prostate cancer patients to DES 1 mg orally three times daily or orchiectomy; or DES, 1 mg, three times daily, plus cyclophosphamide at 1 mg/m 2 iv every three weeks, or cyclophosphamide 1 g/m 2 iv every three weeks plus estramustine phosphate (Estracyt) at 600 mg/m 2 orally daily in three divided doses. There were 246 patients evaluated for response of 301 entered. These consisted of 83 on the DES/orchiectomy arm, 77 on DES plus cyclophosphamide, and 86 on Estracyt plus cyclophosphamide. Objective response rates, initially evaluated at 12 weeks, were similar among the treatments. However, chemotherapy as used in this study early in the diagnosis of metastatic disease appears to exhibit an improved effect on overall survival compared to hormone therapy alone. Analysis within groups having pain versus no pain at entry revealed a marked advantage after 80 weeks for chemotherapy when pain was initially present and a slight advantage during treatment (throughout follow-up) when the pain was absent. Median survival times were 92, 91, and 94 weeks, respectively, for the three treatments. The progression-free interval for responders showed no difference between initial treatments, although nearly one half of the patients are still in remission; hence, further follow-up will be essential. Side effects were not excessive for the chemotherapy treatment arms and patient compliance was good. This national multicenter trial provides the basis for further testing of chemotherapy agents at an earlier phase for patients with newly diagnosed metastatic prostate cancer.

Original languageEnglish (US)
Pages (from-to)1264-1272
Number of pages9
Issue number7
StatePublished - Apr 1 1983

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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