Treatment of nasopharyngeal carcinoma in the modern era

Analysis of outcomes and toxicity from a single center in a nonendemic area

Don Yee, John Hanson, Harold Lau, Jodi Siever, Stefan Gluck

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We analyzed treatment outcomes for nasopharyngeal carcinoma in a single institute. MATERIALS AND METHODS: From 1992 to 2002, 82 patients with nasopharyngeal cancer were treated. Kaplan-Meier estimates of overall and disease-free survival were calculated. The log-rank test was used to determine significant prognostic determinants of overall and disease-free survival. RESULTS: Patients received one of three regimens: radiotherapy alone (n = 19), radiotherapy with concurrent carboplatin (n = 46), or radiotherapy with concurrent cisplatin (n = 17). Fifty-seven percent of patients had their radiotherapy planned using fluoroscopy-based methods. Overall, 93.9% of patients received all prescribed radiotherapy. Response rate to treatment was 98.7%. Three-year disease-free survival and overall survival rates for all patients were 69.0% and 65%, respectively. Five patients had late grade 3-4 toxicities. There were no treatment-related deaths. Twenty-four percent of patients were hospitalized during treatment, and 72.6% lost ≤ 9.9% of pretreatment weight. Forty-two percent of failures were local and 27.3% were distant. Ninety percent of deaths were nasopharyngeal carcinoma-related. Disease stage was the only significant predictor of overall survival. DISCUSSION: At our center, treatments given for nasopharyngeal carcinoma from 1992 to 2002 had acceptable toxicity rates. Further follow-up of patients treated with modern radiotherapy planning methods and chemotherapy regimens is needed to compare our institutional results with other published outcomes with more validity.

Original languageEnglish
Pages (from-to)147-154
Number of pages8
JournalCancer Journal
Volume12
Issue number2
StatePublished - Mar 1 2006
Externally publishedYes

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Radiotherapy
Disease-Free Survival
Therapeutics
Nasopharyngeal Neoplasms
Nasopharyngeal carcinoma
Carboplatin
Fluoroscopy
Kaplan-Meier Estimate
Cisplatin
Survival Rate
Weights and Measures
Drug Therapy
Survival

Keywords

  • Nasopharyngeal cancer
  • Treatment outcomes

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Treatment of nasopharyngeal carcinoma in the modern era : Analysis of outcomes and toxicity from a single center in a nonendemic area. / Yee, Don; Hanson, John; Lau, Harold; Siever, Jodi; Gluck, Stefan.

In: Cancer Journal, Vol. 12, No. 2, 01.03.2006, p. 147-154.

Research output: Contribution to journalArticle

Yee, Don ; Hanson, John ; Lau, Harold ; Siever, Jodi ; Gluck, Stefan. / Treatment of nasopharyngeal carcinoma in the modern era : Analysis of outcomes and toxicity from a single center in a nonendemic area. In: Cancer Journal. 2006 ; Vol. 12, No. 2. pp. 147-154.
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