Treatment of mood disorders

Charles B. Nemeroff, Michael J. Owens

Research output: Contribution to journalArticlepeer-review

215 Scopus citations


Depression is a leading cause of morbidity and mortality, and its treatment includes a high percentage of the medications prescribed by physicians. Available antidepressant drugs are safe and effective, but less than half of all patients attain complete remission after therapy with a single anti-depressant. Others exhibit partial, refractory or intolerant responses to treatment, emphasizing the need to discover new antidepressants. The mechanisms of action of available medications are directing the field toward new research avenues. This review highlights those areas we believe will influence the field and soon lead to better treatment.

Original languageEnglish (US)
Pages (from-to)1068-1070
Number of pages3
JournalNature Neuroscience
Issue number11s
StatePublished - Nov 2002
Externally publishedYes

ASJC Scopus subject areas

  • Neuroscience(all)


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