Treatment of microsporidial keratoconjunctivitis with topical fumagillin

M. C. Diesenhouse, L. A. Wilson, G. F. Corrent, G. S. Visvesvara, H. E. Grossniklaus, R. T. Bryan

Research output: Contribution to journalArticle

93 Citations (Scopus)

Abstract

Encephalitozoon hellem is a newly described cause of microsporidial keratoconjunctivitis, occurring chiefly in patients with significantly diminished CD4+ T-lymphocyte levels. This disorder is symptomatically disabling and generally recalcitrant to topical antimicrobial therapy. Two homosexual men with E. hellem keratoconjunctivitis diagnosed by Gram stain, transmission electron microscopy, and specific indirect immunofluorescent assay were treated with topical fumagillin (Fumidil B). Both patients had marked symptomatic improvement with reduction of clinical findings. Symptoms and signs recurred with temporary discontinuation of the drug. Both patients, however, remained symptom-free on maintenance levels of topical fumagillin with no evidence of toxic side effects.

Original languageEnglish
Pages (from-to)293-298
Number of pages6
JournalAmerican Journal of Ophthalmology
Volume115
Issue number3
StatePublished - Jan 1 1993

Fingerprint

Keratoconjunctivitis
Encephalitozoon
Poisons
Transmission Electron Microscopy
Signs and Symptoms
Therapeutics
Maintenance
T-Lymphocytes
Pharmaceutical Preparations
fumagillin

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Diesenhouse, M. C., Wilson, L. A., Corrent, G. F., Visvesvara, G. S., Grossniklaus, H. E., & Bryan, R. T. (1993). Treatment of microsporidial keratoconjunctivitis with topical fumagillin. American Journal of Ophthalmology, 115(3), 293-298.

Treatment of microsporidial keratoconjunctivitis with topical fumagillin. / Diesenhouse, M. C.; Wilson, L. A.; Corrent, G. F.; Visvesvara, G. S.; Grossniklaus, H. E.; Bryan, R. T.

In: American Journal of Ophthalmology, Vol. 115, No. 3, 01.01.1993, p. 293-298.

Research output: Contribution to journalArticle

Diesenhouse, MC, Wilson, LA, Corrent, GF, Visvesvara, GS, Grossniklaus, HE & Bryan, RT 1993, 'Treatment of microsporidial keratoconjunctivitis with topical fumagillin', American Journal of Ophthalmology, vol. 115, no. 3, pp. 293-298.
Diesenhouse MC, Wilson LA, Corrent GF, Visvesvara GS, Grossniklaus HE, Bryan RT. Treatment of microsporidial keratoconjunctivitis with topical fumagillin. American Journal of Ophthalmology. 1993 Jan 1;115(3):293-298.
Diesenhouse, M. C. ; Wilson, L. A. ; Corrent, G. F. ; Visvesvara, G. S. ; Grossniklaus, H. E. ; Bryan, R. T. / Treatment of microsporidial keratoconjunctivitis with topical fumagillin. In: American Journal of Ophthalmology. 1993 ; Vol. 115, No. 3. pp. 293-298.
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