Treatment of large HCC: Transcatheter arterial chemoembolization combined with percutaneous ethanol injection versus repeated transcatheter arterial chemoembolization

Carlo Bartolozzi, Riccardo Lencioni, Davide Caramella, Claudio Vignali, Roberto Cioni, Salvatore Mazzeo, Mario Carrai, Giacomo Maltinti, Alfonso Capria, Pier Franco Conte

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186 Scopus citations

Abstract

PURPOSE: To compare the efficacy of transcatheter arterial chemoembolization (TACE) combined with percutaneous ethanol injection (PEI) versus repeated TACE in the treatment of large hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Fifty-three patients with cirrhosis and a large HCC (main tumor, 3.1-8.0 cm in diameter with no more than two daughter nodules) were enrolled in a prospective, randomized study. Twenty-six patients underwent a single TACE session followed by PEI (TACE-PEI group), whereas 27 patients underwent two to five TACE sessions (TACE group). Both groups of patients were similar with regard to liver function. Follow-up ranged from 8 to 39 months. RESULTS: Complete therapeutic responses were higher (P < .05) and tumor recurrences during follow-up were lower (P < .05) in the TACE-PEI group than in the TACE group. Patients in the TACE-PEI group survived longer than those in the TACE group, although the difference was not significant (P > .1). The rates of survival without recurrence were better in the TACE-PEI group than in the TACE group (P < .05). CONCLUSION: Use of a single TACE session combined with PEI is more effective than repeated TACE in the treatment of large HCC.

Original languageEnglish (US)
Pages (from-to)812-818
Number of pages7
JournalRadiology
Volume197
Issue number3
DOIs
StatePublished - Dec 1995

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Keywords

  • Alcohol
  • Liver neoplasms
  • Liver neoplasms, chemotherapeutic infusion
  • Liver neoplasms, therapy
  • Liver, interventional procedure

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Bartolozzi, C., Lencioni, R., Caramella, D., Vignali, C., Cioni, R., Mazzeo, S., Carrai, M., Maltinti, G., Capria, A., & Conte, P. F. (1995). Treatment of large HCC: Transcatheter arterial chemoembolization combined with percutaneous ethanol injection versus repeated transcatheter arterial chemoembolization. Radiology, 197(3), 812-818. https://doi.org/10.1148/radiology.197.3.7480761