Abstract
PURPOSE: To compare the efficacy of transcatheter arterial chemoembolization (TACE) combined with percutaneous ethanol injection (PEI) versus repeated TACE in the treatment of large hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Fifty-three patients with cirrhosis and a large HCC (main tumor, 3.1-8.0 cm in diameter with no more than two daughter nodules) were enrolled in a prospective, randomized study. Twenty-six patients underwent a single TACE session followed by PEI (TACE-PEI group), whereas 27 patients underwent two to five TACE sessions (TACE group). Both groups of patients were similar with regard to liver function. Follow-up ranged from 8 to 39 months. RESULTS: Complete therapeutic responses were higher (P <.05) and tumor recurrences during follow-up were lower (P <.05) in the TACE-PEI group than in the TACE group. Patients in the TACE-PEI group survived longer than those in the TACE group, although the difference was not significant (P > .1). The rates of survival without recurrence were better in the TACE-PEI group than in the TACE group (P <.05). CONCLUSION: Use of a single TACE session combined with PEI is more effective than repeated TACE in the treatment of large HCC.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 812-818 |
| Number of pages | 7 |
| Journal | Radiology |
| Volume | 197 |
| Issue number | 3 |
| State | Published - 1995 |
| Externally published | Yes |
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Keywords
- Alcohol
- Liver neoplasms
- Liver neoplasms, chemotherapeutic infusion
- Liver neoplasms, therapy
- Liver, interventional procedure
ASJC Scopus subject areas
- Radiological and Ultrasound Technology
Cite this
Treatment of large HCC : Transcatheter arterial chemoembolization combined with percutaneous ethanol injection versus repeated transcatheter arterial chemoembolization. / Bartolozzi, C.; Lencioni, Riccardo; Caramella, D.; Vignali, C.; Cioni, R.; Mazzeo, S.; Carrai, M.; Maltinti, G.; Capria, A.; Conte, P. F.
In: Radiology, Vol. 197, No. 3, 1995, p. 812-818.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment of large HCC
T2 - Transcatheter arterial chemoembolization combined with percutaneous ethanol injection versus repeated transcatheter arterial chemoembolization
AU - Bartolozzi, C.
AU - Lencioni, Riccardo
AU - Caramella, D.
AU - Vignali, C.
AU - Cioni, R.
AU - Mazzeo, S.
AU - Carrai, M.
AU - Maltinti, G.
AU - Capria, A.
AU - Conte, P. F.
PY - 1995
Y1 - 1995
N2 - PURPOSE: To compare the efficacy of transcatheter arterial chemoembolization (TACE) combined with percutaneous ethanol injection (PEI) versus repeated TACE in the treatment of large hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Fifty-three patients with cirrhosis and a large HCC (main tumor, 3.1-8.0 cm in diameter with no more than two daughter nodules) were enrolled in a prospective, randomized study. Twenty-six patients underwent a single TACE session followed by PEI (TACE-PEI group), whereas 27 patients underwent two to five TACE sessions (TACE group). Both groups of patients were similar with regard to liver function. Follow-up ranged from 8 to 39 months. RESULTS: Complete therapeutic responses were higher (P <.05) and tumor recurrences during follow-up were lower (P <.05) in the TACE-PEI group than in the TACE group. Patients in the TACE-PEI group survived longer than those in the TACE group, although the difference was not significant (P > .1). The rates of survival without recurrence were better in the TACE-PEI group than in the TACE group (P <.05). CONCLUSION: Use of a single TACE session combined with PEI is more effective than repeated TACE in the treatment of large HCC.
AB - PURPOSE: To compare the efficacy of transcatheter arterial chemoembolization (TACE) combined with percutaneous ethanol injection (PEI) versus repeated TACE in the treatment of large hepatocellular carcinoma (HCC). MATERIALS AND METHODS: Fifty-three patients with cirrhosis and a large HCC (main tumor, 3.1-8.0 cm in diameter with no more than two daughter nodules) were enrolled in a prospective, randomized study. Twenty-six patients underwent a single TACE session followed by PEI (TACE-PEI group), whereas 27 patients underwent two to five TACE sessions (TACE group). Both groups of patients were similar with regard to liver function. Follow-up ranged from 8 to 39 months. RESULTS: Complete therapeutic responses were higher (P <.05) and tumor recurrences during follow-up were lower (P <.05) in the TACE-PEI group than in the TACE group. Patients in the TACE-PEI group survived longer than those in the TACE group, although the difference was not significant (P > .1). The rates of survival without recurrence were better in the TACE-PEI group than in the TACE group (P <.05). CONCLUSION: Use of a single TACE session combined with PEI is more effective than repeated TACE in the treatment of large HCC.
KW - Alcohol
KW - Liver neoplasms
KW - Liver neoplasms, chemotherapeutic infusion
KW - Liver neoplasms, therapy
KW - Liver, interventional procedure
UR - http://www.scopus.com/inward/record.url?scp=0028861999&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028861999&partnerID=8YFLogxK
M3 - Article
VL - 197
SP - 812
EP - 818
JO - Radiology
JF - Radiology
SN - 0033-8419
IS - 3
ER -