Treatment of Hailey-Hailey disease with tacrolimus ointment and clobetasol propionate foam.

Saleem A. Umar, Pradip Bhattacharjee, Robert T. Brodell

Research output: Contribution to journalArticle

21 Scopus citations


Hailey-Hailey disease, or familial benign chronic pemphigus, is a chronic disease without a known cure. Current therapeutic strategies attempt to suppress Hailey-Hailey outbreaks and allow the patient to live comfortably with this condition. We have found that applying topical tacrolimus 0.1% ointment (Protopic) twice a day to affected areas is an excellent way to control Hailey-Hailey disease. In addition to effectively controlling Hailey-Hailey outbreaks, tacrolimus is a relatively safe and noninvasive mode of treatment, without significant side effects. We recommend intermittent therapy with clobetasol propionate 0.05% foam (Olux Foam) for patients who break through suppressive therapy with tacrolimus a few times per year. In patients with frequent outbreaks of Hailey-Hailey disease despite suppressive therapy with tacrolimus, we recommend alternating the tacrolimus with clobetasol propionate 0.05% foam every 6 weeks.

Original languageEnglish (US)
Pages (from-to)200-203
Number of pages4
JournalJournal of drugs in dermatology : JDD
Issue number2
StatePublished - Jan 1 2004


ASJC Scopus subject areas

  • Dermatology

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