Treatment of extra - abdominal desmoid tumors with chemotherapy

Corey Montgomery, Cynthia Emory, Sheila Adams, Jonathan Cohen, John David Pitcher, Benjamin Kyle Potter, H. Thomas Temple

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

Fibromatosis, or extra-abdominal desmoid tumor, is a benign disease which often has an aggressive clinical course that can be difficult to treat. We performed a retrospective review of 16 patients (12 females and four males) with a mean age of 34.2 years treated with methotrexate and vinblastine for newly diagnosed or recurrent extra-abdominal desmoid tumor. The mean age of our patient cohort was 34.2 years (range 11-70), and the mean tumor size was 11.5 cm (range 2.5-21.2 cm). The mean duration of therapy was 12 months with an average follow-up of 43 months (range 1-149 months). Fourteen of 16 patients demonstrated a clinical response to treatment. Eight of 14 patients demonstrated a radiologic decrease in tumor size. Only one patient progressed on therapy. Six patients developed recurrent symptoms after discontinuation of treatment. Chemotherapy-related symptoms including neutropenia, nausea, and vomiting were common and observed in most patients, however these side effects were mild and transient. Five patients developed peripheral neuropathy that prompted a change from vinblastine to vinorelbine during treatment. One potentially life-threatening complication (pneumocystis pneumonia) occurred which was diagnosed early and successfully treated. The use of methotrexate and vinblastine/vinorelbine in the management of fibromatosis appears to be an effective treatment with minimal treatment-related side effects.

Original languageEnglish (US)
Pages (from-to)3394-3404
Number of pages11
JournalCancers
Volume3
Issue number3
DOIs
StatePublished - Sep 1 2011

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Keywords

  • Chemotherapy
  • Desmoid tumors
  • Fibromatosis
  • Methotrexate
  • Vinblastine
  • Vinorelbine

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Montgomery, C., Emory, C., Adams, S., Cohen, J., Pitcher, J. D., Potter, B. K., & Temple, H. T. (2011). Treatment of extra - abdominal desmoid tumors with chemotherapy. Cancers, 3(3), 3394-3404. https://doi.org/10.3390/cancers3033394