Treatment of dry age-related macular degeneration

Giuseppe Querques, Philip J. Rosenfeld, Edoardo Cavallero, Enrico Borrelli, Federico Corvi, Lea Querques, Francesco M. Bandello, Marco A. Zarbin

Research output: Contribution to journalReview article

24 Scopus citations

Abstract

A number of different approaches are under development for treating nonexudative manifestations of age-related macular degeneration (AMD). Some interventions target specific pathways that are believed to play a role in AMD pathogenesis, e.g. oxidative damage, lipofuscin accumulation, chronic inflammation (including complement activation), extracellular matrix changes (e.g. β-amyloid accumulation), impaired choroidal blood flow, and apoptosis. In principle, these therapies can be combined ('combination therapy'), which may lead to synergistic effects that include better visual outcome, less likelihood for 'escape' (i.e. drug resistance), and less frequent treatment

Original languageEnglish (US)
Pages (from-to)107-115
Number of pages9
JournalOphthalmic Research
Volume52
Issue number3
DOIs
StatePublished - Nov 19 2014

Keywords

  • Age-related macular degeneration
  • Drugs
  • Drusen
  • Geographic atrophy
  • Neurotrophic factors
  • Oxidative damage
  • Pathway
  • Stem cells
  • Treatment
  • Visual cycle

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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  • Cite this

    Querques, G., Rosenfeld, P. J., Cavallero, E., Borrelli, E., Corvi, F., Querques, L., Bandello, F. M., & Zarbin, M. A. (2014). Treatment of dry age-related macular degeneration. Ophthalmic Research, 52(3), 107-115. https://doi.org/10.1159/000363187