Treatment of dry age-related macular degeneration

Giuseppe Querques; Philip J. Rosenfeld; Edoardo Cavallero; Enrico Borrelli; Federico Corvi; Lea Querques; Francesco M. Bandello; Marco A. Zarbin

doi:10.1159/000363187

Treatment of dry age-related macular degeneration

Giuseppe Querques, Philip J. Rosenfeld, Edoardo Cavallero, Enrico Borrelli, Federico Corvi, Lea Querques, Francesco M. Bandello, Marco A. Zarbin

Ophthalmology

Research output: Contribution to journal › Review article › peer-review

28 Scopus citations

Abstract

A number of different approaches are under development for treating nonexudative manifestations of age-related macular degeneration (AMD). Some interventions target specific pathways that are believed to play a role in AMD pathogenesis, e.g. oxidative damage, lipofuscin accumulation, chronic inflammation (including complement activation), extracellular matrix changes (e.g. β-amyloid accumulation), impaired choroidal blood flow, and apoptosis. In principle, these therapies can be combined ('combination therapy'), which may lead to synergistic effects that include better visual outcome, less likelihood for 'escape' (i.e. drug resistance), and less frequent treatment

Original language	English (US)
Pages (from-to)	107-115
Number of pages	9
Journal	Ophthalmic Research
Volume	52
Issue number	3
DOIs	https://doi.org/10.1159/000363187
State	Published - Nov 19 2014

Keywords

Age-related macular degeneration
Drugs
Drusen
Geographic atrophy
Neurotrophic factors
Oxidative damage
Pathway
Stem cells
Treatment
Visual cycle

ASJC Scopus subject areas

Ophthalmology
Sensory Systems
Cellular and Molecular Neuroscience

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title = "Treatment of dry age-related macular degeneration",

abstract = "A number of different approaches are under development for treating nonexudative manifestations of age-related macular degeneration (AMD). Some interventions target specific pathways that are believed to play a role in AMD pathogenesis, e.g. oxidative damage, lipofuscin accumulation, chronic inflammation (including complement activation), extracellular matrix changes (e.g. β-amyloid accumulation), impaired choroidal blood flow, and apoptosis. In principle, these therapies can be combined ('combination therapy'), which may lead to synergistic effects that include better visual outcome, less likelihood for 'escape' (i.e. drug resistance), and less frequent treatment",

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AU - Rosenfeld, Philip J.

AU - Cavallero, Edoardo

AU - Borrelli, Enrico

AU - Corvi, Federico

AU - Querques, Lea

AU - Bandello, Francesco M.

AU - Zarbin, Marco A.

PY - 2014/11/19

Y1 - 2014/11/19

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KW - Age-related macular degeneration

KW - Drugs

KW - Drusen

KW - Geographic atrophy

KW - Neurotrophic factors

KW - Oxidative damage

KW - Pathway

KW - Stem cells

KW - Treatment

KW - Visual cycle

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Treatment of dry age-related macular degeneration

Abstract

Keywords

ASJC Scopus subject areas

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