Abstract
INTRODUCTION: Combination UVA irradiation (PUVA) and photophoresis as an option for the treatment of cutaneous T-cell lymphoma (CTCL). METHODS: Two patients with CTCL, who had demonstrated clinical response to therapy with a variety of agents (including photochemotherapy and photophoresis) followed by relapses, were placed on a treatment regimen combining photophoresis every 4 to 8 weeks with PUVA four times per week. RESULTS: There was a decrease in the size of existing lesions, arrest of new tumor development, and resolution of lymphadenopathy. These patients who had become unresponsive to both PUVA and photophoresis, individually, were successfully treated with combination therapy and have not relapsed over an 8-month period. CONCLUSION: The combination of PUVA and photophoresis may act synergistically resulting in clinical improvement in patients with CTCL.
| Original language | English |
|---|---|
| Pages (from-to) | 105-107 |
| Number of pages | 3 |
| Journal | Journal of Dermatological Treatment |
| Volume | 11 |
| Issue number | 2 |
| State | Published - Jun 1 2000 |
| Externally published | Yes |
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Keywords
- CTCL
- Photophoresis
- PUVA
ASJC Scopus subject areas
- Dermatology
Cite this
Treatment of cutaneous T-cell lymphoma with the combination extracorporeal photochemotherapy and conventional psoralen ultraviolet A irradiation. / Sanchez, J.; Kirsner, Robert; Cohen, J.; Kerdel, Francisco A.
In: Journal of Dermatological Treatment, Vol. 11, No. 2, 01.06.2000, p. 105-107.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment of cutaneous T-cell lymphoma with the combination extracorporeal photochemotherapy and conventional psoralen ultraviolet A irradiation
AU - Sanchez, J.
AU - Kirsner, Robert
AU - Cohen, J.
AU - Kerdel, Francisco A.
PY - 2000/6/1
Y1 - 2000/6/1
N2 - INTRODUCTION: Combination UVA irradiation (PUVA) and photophoresis as an option for the treatment of cutaneous T-cell lymphoma (CTCL). METHODS: Two patients with CTCL, who had demonstrated clinical response to therapy with a variety of agents (including photochemotherapy and photophoresis) followed by relapses, were placed on a treatment regimen combining photophoresis every 4 to 8 weeks with PUVA four times per week. RESULTS: There was a decrease in the size of existing lesions, arrest of new tumor development, and resolution of lymphadenopathy. These patients who had become unresponsive to both PUVA and photophoresis, individually, were successfully treated with combination therapy and have not relapsed over an 8-month period. CONCLUSION: The combination of PUVA and photophoresis may act synergistically resulting in clinical improvement in patients with CTCL.
AB - INTRODUCTION: Combination UVA irradiation (PUVA) and photophoresis as an option for the treatment of cutaneous T-cell lymphoma (CTCL). METHODS: Two patients with CTCL, who had demonstrated clinical response to therapy with a variety of agents (including photochemotherapy and photophoresis) followed by relapses, were placed on a treatment regimen combining photophoresis every 4 to 8 weeks with PUVA four times per week. RESULTS: There was a decrease in the size of existing lesions, arrest of new tumor development, and resolution of lymphadenopathy. These patients who had become unresponsive to both PUVA and photophoresis, individually, were successfully treated with combination therapy and have not relapsed over an 8-month period. CONCLUSION: The combination of PUVA and photophoresis may act synergistically resulting in clinical improvement in patients with CTCL.
KW - CTCL
KW - Photophoresis
KW - PUVA
UR - http://www.scopus.com/inward/record.url?scp=0033944399&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0033944399&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0033944399
VL - 11
SP - 105
EP - 107
JO - Journal of Dermatological Treatment
JF - Journal of Dermatological Treatment
SN - 0954-6634
IS - 2
ER -