Treatment of cutaneous T-cell lymphoma with the combination extracorporeal photochemotherapy and conventional psoralen ultraviolet A irradiation

J. Sanchez, Robert Kirsner, J. Cohen, Francisco A. Kerdel

Research output: Contribution to journalArticle

Abstract

INTRODUCTION: Combination UVA irradiation (PUVA) and photophoresis as an option for the treatment of cutaneous T-cell lymphoma (CTCL). METHODS: Two patients with CTCL, who had demonstrated clinical response to therapy with a variety of agents (including photochemotherapy and photophoresis) followed by relapses, were placed on a treatment regimen combining photophoresis every 4 to 8 weeks with PUVA four times per week. RESULTS: There was a decrease in the size of existing lesions, arrest of new tumor development, and resolution of lymphadenopathy. These patients who had become unresponsive to both PUVA and photophoresis, individually, were successfully treated with combination therapy and have not relapsed over an 8-month period. CONCLUSION: The combination of PUVA and photophoresis may act synergistically resulting in clinical improvement in patients with CTCL.

Original languageEnglish
Pages (from-to)105-107
Number of pages3
JournalJournal of Dermatological Treatment
Volume11
Issue number2
StatePublished - Jun 1 2000
Externally publishedYes

Fingerprint

Photopheresis
Ficusin
Cutaneous T-Cell Lymphoma
Photochemotherapy
Therapeutics
Recurrence
Neoplasms

Keywords

  • CTCL
  • Photophoresis
  • PUVA

ASJC Scopus subject areas

  • Dermatology

Cite this

Treatment of cutaneous T-cell lymphoma with the combination extracorporeal photochemotherapy and conventional psoralen ultraviolet A irradiation. / Sanchez, J.; Kirsner, Robert; Cohen, J.; Kerdel, Francisco A.

In: Journal of Dermatological Treatment, Vol. 11, No. 2, 01.06.2000, p. 105-107.

Research output: Contribution to journalArticle

@article{35e24c6a4d7b44fd93e6fd53f8b67a65,
title = "Treatment of cutaneous T-cell lymphoma with the combination extracorporeal photochemotherapy and conventional psoralen ultraviolet A irradiation",
abstract = "INTRODUCTION: Combination UVA irradiation (PUVA) and photophoresis as an option for the treatment of cutaneous T-cell lymphoma (CTCL). METHODS: Two patients with CTCL, who had demonstrated clinical response to therapy with a variety of agents (including photochemotherapy and photophoresis) followed by relapses, were placed on a treatment regimen combining photophoresis every 4 to 8 weeks with PUVA four times per week. RESULTS: There was a decrease in the size of existing lesions, arrest of new tumor development, and resolution of lymphadenopathy. These patients who had become unresponsive to both PUVA and photophoresis, individually, were successfully treated with combination therapy and have not relapsed over an 8-month period. CONCLUSION: The combination of PUVA and photophoresis may act synergistically resulting in clinical improvement in patients with CTCL.",
keywords = "CTCL, Photophoresis, PUVA",
author = "J. Sanchez and Robert Kirsner and J. Cohen and Kerdel, {Francisco A.}",
year = "2000",
month = "6",
day = "1",
language = "English",
volume = "11",
pages = "105--107",
journal = "Journal of Dermatological Treatment",
issn = "0954-6634",
publisher = "Informa Healthcare",
number = "2",

}

TY - JOUR

T1 - Treatment of cutaneous T-cell lymphoma with the combination extracorporeal photochemotherapy and conventional psoralen ultraviolet A irradiation

AU - Sanchez, J.

AU - Kirsner, Robert

AU - Cohen, J.

AU - Kerdel, Francisco A.

PY - 2000/6/1

Y1 - 2000/6/1

N2 - INTRODUCTION: Combination UVA irradiation (PUVA) and photophoresis as an option for the treatment of cutaneous T-cell lymphoma (CTCL). METHODS: Two patients with CTCL, who had demonstrated clinical response to therapy with a variety of agents (including photochemotherapy and photophoresis) followed by relapses, were placed on a treatment regimen combining photophoresis every 4 to 8 weeks with PUVA four times per week. RESULTS: There was a decrease in the size of existing lesions, arrest of new tumor development, and resolution of lymphadenopathy. These patients who had become unresponsive to both PUVA and photophoresis, individually, were successfully treated with combination therapy and have not relapsed over an 8-month period. CONCLUSION: The combination of PUVA and photophoresis may act synergistically resulting in clinical improvement in patients with CTCL.

AB - INTRODUCTION: Combination UVA irradiation (PUVA) and photophoresis as an option for the treatment of cutaneous T-cell lymphoma (CTCL). METHODS: Two patients with CTCL, who had demonstrated clinical response to therapy with a variety of agents (including photochemotherapy and photophoresis) followed by relapses, were placed on a treatment regimen combining photophoresis every 4 to 8 weeks with PUVA four times per week. RESULTS: There was a decrease in the size of existing lesions, arrest of new tumor development, and resolution of lymphadenopathy. These patients who had become unresponsive to both PUVA and photophoresis, individually, were successfully treated with combination therapy and have not relapsed over an 8-month period. CONCLUSION: The combination of PUVA and photophoresis may act synergistically resulting in clinical improvement in patients with CTCL.

KW - CTCL

KW - Photophoresis

KW - PUVA

UR - http://www.scopus.com/inward/record.url?scp=0033944399&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033944399&partnerID=8YFLogxK

M3 - Article

VL - 11

SP - 105

EP - 107

JO - Journal of Dermatological Treatment

JF - Journal of Dermatological Treatment

SN - 0954-6634

IS - 2

ER -