Abstract
Background: Recent evidence indicates that bone marrow contains stem cells with the potential for differentiation into a variety of tissues, including endothelium, liver, muscle, bone, and skin. It may thus be plausible that bone marrow-derived cells can provide progenitor and/or stem cells to wounds during healing. Our objective in this study was to establish proof of principle that bone marrow-derived cells applied to chronic wounds can lead to closure of nonhealing wounds. We applied autologous bone marrow cells to chronic wounds in 3 patients with wounds of more than 1-year duration. These patients had not previously responded to standard and advanced therapies, including bioengineered skin application and grafting with autologous skin, Observations: Complete closure and evidence of dermal rebuilding was observed in all patients. Find ings suggesting engraftment of applied cells was observed in biopsy specimens of treated wounds. Clinical and histologic evidence of reduced scarring was also observed. Conclusion: Directly applied bone marrow-derived cell: can lead to dermal rebuilding and closure of nonhealing chronic wounds.
| Original language | English |
|---|---|
| Pages (from-to) | 510-516 |
| Number of pages | 7 |
| Journal | Archives of Dermatology |
| Volume | 139 |
| Issue number | 4 |
| DOIs | |
| State | Published - Apr 1 2003 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Dermatology
Cite this
Treatment of chronic wounds with bone marrow-derived cells. / Badiavas, Evangelos V; Falanga, Vincent.
In: Archives of Dermatology, Vol. 139, No. 4, 01.04.2003, p. 510-516.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Treatment of chronic wounds with bone marrow-derived cells
AU - Badiavas, Evangelos V
AU - Falanga, Vincent
PY - 2003/4/1
Y1 - 2003/4/1
N2 - Background: Recent evidence indicates that bone marrow contains stem cells with the potential for differentiation into a variety of tissues, including endothelium, liver, muscle, bone, and skin. It may thus be plausible that bone marrow-derived cells can provide progenitor and/or stem cells to wounds during healing. Our objective in this study was to establish proof of principle that bone marrow-derived cells applied to chronic wounds can lead to closure of nonhealing wounds. We applied autologous bone marrow cells to chronic wounds in 3 patients with wounds of more than 1-year duration. These patients had not previously responded to standard and advanced therapies, including bioengineered skin application and grafting with autologous skin, Observations: Complete closure and evidence of dermal rebuilding was observed in all patients. Find ings suggesting engraftment of applied cells was observed in biopsy specimens of treated wounds. Clinical and histologic evidence of reduced scarring was also observed. Conclusion: Directly applied bone marrow-derived cell: can lead to dermal rebuilding and closure of nonhealing chronic wounds.
AB - Background: Recent evidence indicates that bone marrow contains stem cells with the potential for differentiation into a variety of tissues, including endothelium, liver, muscle, bone, and skin. It may thus be plausible that bone marrow-derived cells can provide progenitor and/or stem cells to wounds during healing. Our objective in this study was to establish proof of principle that bone marrow-derived cells applied to chronic wounds can lead to closure of nonhealing wounds. We applied autologous bone marrow cells to chronic wounds in 3 patients with wounds of more than 1-year duration. These patients had not previously responded to standard and advanced therapies, including bioengineered skin application and grafting with autologous skin, Observations: Complete closure and evidence of dermal rebuilding was observed in all patients. Find ings suggesting engraftment of applied cells was observed in biopsy specimens of treated wounds. Clinical and histologic evidence of reduced scarring was also observed. Conclusion: Directly applied bone marrow-derived cell: can lead to dermal rebuilding and closure of nonhealing chronic wounds.
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UR - http://www.scopus.com/inward/citedby.url?scp=0037390253&partnerID=8YFLogxK
U2 - 10.1001/archderm.139.4.510
DO - 10.1001/archderm.139.4.510
M3 - Article
C2 - 12707099
AN - SCOPUS:0037390253
VL - 139
SP - 510
EP - 516
JO - JAMA Dermatology
JF - JAMA Dermatology
SN - 2168-6068
IS - 4
ER -