Treatment of Autoimmune Hemolytic Anemia With Vinca-Loaded Platelets

Yeon Ahn, William J. Harrington, John Byrnes, Lorraine Pall, Janice McCrainie

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

We worked with a new strategy for the treatment of autoimmune hemolytic anemia (AIHA) of the warm antibody type. Platelets were loaded with Vinca alkaloids and reacted with antiplatelet antibodies to facilitate their phagocytosis by macrophages, resulting in a measure of selective delivery of the drugs to the cells of the mononuclear phagocyte system, which destroy RBCs in AIHA. Four patients were studied. Three with AIHA refractory to splenectomy and the use of moderate doses of glucocorticoids achieved hematologic and clinical remissions. Administration of steroids was either discontinued or reduced to minimal doses after treatment. Remissions lasted three years in two patients and one year in the other. Responses were characterized by prompt prolongation of RBC survival, correction of anemia, and gradual decrease in cell-bound antibody. In one nonsplenectomized patient, the disorder did not respond. Platelet— Vinca alkaloid complex is useful in the treatment of AIHA refractory to splenectomy and use of steroids.

Original languageEnglish (US)
Pages (from-to)2189-2194
Number of pages6
JournalJAMA - Journal of the American Medical Association
Volume249
Issue number16
DOIs
StatePublished - Apr 22 1983

ASJC Scopus subject areas

  • Medicine(all)

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