Treatment of Alopecia Areata with Simvastatin/Ezetimibe

Jessica Cervantes; Joaquin J Jimenez; Gina M. DelCanto; Antonella Tosti

doi:10.1016/j.jisp.2017.10.013

Treatment of Alopecia Areata with Simvastatin/Ezetimibe

Jessica Cervantes, Joaquin J Jimenez, Gina M. DelCanto, Antonella Tosti

Dermatology & Cutaneous Surgery

Research output: Contribution to journal › Review article

4 Scopus citations

Abstract

Alopecia areata (AA) is an autoimmune disorder characterized by T lymphocytic infiltrates around the bulbar region of hair follicles. Statins have surfaced as potential therapeutic agents for AA, partly because of their modulation of the JAK/STAT pathway. Some data indicate that statins are a possible option for acute, but not chronic, longstanding AA. Animal studies suggest that treatment with statins increases CD4⁺/CD25⁺/Foxp3⁺ populations in AA-affected mice.

Original language	English (US)
Pages (from-to)	S25-S31
Journal	Journal of Investigative Dermatology Symposium Proceedings
Volume	19
Issue number	1
DOIs	https://doi.org/10.1016/j.jisp.2017.10.013
State	Published - Jan 1 2018

ASJC Scopus subject areas

Biotechnology
Molecular Biology
Dermatology
Cell Biology

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Cervantes, J., Jimenez, J. J., DelCanto, G. M., & Tosti, A. (2018). Treatment of Alopecia Areata with Simvastatin/Ezetimibe. Journal of Investigative Dermatology Symposium Proceedings, 19(1), S25-S31. https://doi.org/10.1016/j.jisp.2017.10.013

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abstract = "Alopecia areata (AA) is an autoimmune disorder characterized by T lymphocytic infiltrates around the bulbar region of hair follicles. Statins have surfaced as potential therapeutic agents for AA, partly because of their modulation of the JAK/STAT pathway. Some data indicate that statins are a possible option for acute, but not chronic, longstanding AA. Animal studies suggest that treatment with statins increases CD4+/CD25+/Foxp3+ populations in AA-affected mice.",

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