Abstract
Alopecia areata (AA) is an autoimmune disorder characterized by T lymphocytic infiltrates around the bulbar region of hair follicles. Statins have surfaced as potential therapeutic agents for AA, partly because of their modulation of the JAK/STAT pathway. Some data indicate that statins are a possible option for acute, but not chronic, longstanding AA. Animal studies suggest that treatment with statins increases CD4+/CD25+/Foxp3+ populations in AA-affected mice.
| Original language | English (US) |
|---|---|
| Pages (from-to) | S25-S31 |
| Journal | Journal of Investigative Dermatology Symposium Proceedings |
| Volume | 19 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 1 2018 |
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ASJC Scopus subject areas
- Biotechnology
- Molecular Biology
- Dermatology
- Cell Biology
Cite this
Treatment of Alopecia Areata with Simvastatin/Ezetimibe. / Cervantes, Jessica; Jimenez, Joaquin J; DelCanto, Gina M.; Tosti, Antonella.
In: Journal of Investigative Dermatology Symposium Proceedings, Vol. 19, No. 1, 01.01.2018, p. S25-S31.Research output: Contribution to journal › Review article
}
TY - JOUR
T1 - Treatment of Alopecia Areata with Simvastatin/Ezetimibe
AU - Cervantes, Jessica
AU - Jimenez, Joaquin J
AU - DelCanto, Gina M.
AU - Tosti, Antonella
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Alopecia areata (AA) is an autoimmune disorder characterized by T lymphocytic infiltrates around the bulbar region of hair follicles. Statins have surfaced as potential therapeutic agents for AA, partly because of their modulation of the JAK/STAT pathway. Some data indicate that statins are a possible option for acute, but not chronic, longstanding AA. Animal studies suggest that treatment with statins increases CD4+/CD25+/Foxp3+ populations in AA-affected mice.
AB - Alopecia areata (AA) is an autoimmune disorder characterized by T lymphocytic infiltrates around the bulbar region of hair follicles. Statins have surfaced as potential therapeutic agents for AA, partly because of their modulation of the JAK/STAT pathway. Some data indicate that statins are a possible option for acute, but not chronic, longstanding AA. Animal studies suggest that treatment with statins increases CD4+/CD25+/Foxp3+ populations in AA-affected mice.
UR - http://www.scopus.com/inward/record.url?scp=85039968187&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85039968187&partnerID=8YFLogxK
U2 - 10.1016/j.jisp.2017.10.013
DO - 10.1016/j.jisp.2017.10.013
M3 - Review article
C2 - 29273101
AN - SCOPUS:85039968187
VL - 19
SP - S25-S31
JO - Journal of Investigative Dermatology Symposium Proceedings
JF - Journal of Investigative Dermatology Symposium Proceedings
SN - 1087-0024
IS - 1
ER -