Treatment before liver transplantation for HCC

J. Belghiti, B. I. Carr, P. D. Greig, Riccardo Lencioni, R. T. Poon

Research output: Contribution to journalArticle

100 Citations (Scopus)

Abstract

Liver transplantation (LT) which is currently an established therapy for sma1l, early stage hepatocellular carcinoma (HCC) in patients with cirrhosis requires in most cases long waiting period. Tumor development during the waiting period may be associated with vascular invasion which is a strong factor of postoperative recurrence. Therefore, local treatment of the tumor including trans-arterial chemoembolization (TACE), percutaneous radiofrequency (RF) or partial liver resection can be used before transplantation. In the present paper we reviewed the efficacy of these treatments prior to LT. Although, TACE induced complete tumor necrosis in some patients there is no convincing arguments showing that this treatment reduces the rate of drop out before LT, nor improves the survival after LT. Although, RF can induce complete necrosis in the majority of small tumors (

Original languageEnglish (US)
Pages (from-to)993-1000
Number of pages8
JournalAnnals of Surgical Oncology
Volume15
Issue number4
DOIs
StatePublished - Apr 2008
Externally publishedYes

Fingerprint

Liver Transplantation
Hepatocellular Carcinoma
Neoplasms
Necrosis
Therapeutics
Blood Vessels
Fibrosis
Transplantation
Recurrence
Survival
Liver

Keywords

  • Downstaging
  • Dropout
  • Hepatocellular carcinoma
  • Radiofrequency ablation
  • Resection
  • Transarterial chemoembolization
  • Transplantation

ASJC Scopus subject areas

  • Surgery
  • Oncology

Cite this

Belghiti, J., Carr, B. I., Greig, P. D., Lencioni, R., & Poon, R. T. (2008). Treatment before liver transplantation for HCC. Annals of Surgical Oncology, 15(4), 993-1000. https://doi.org/10.1245/s10434-007-9787-8

Treatment before liver transplantation for HCC. / Belghiti, J.; Carr, B. I.; Greig, P. D.; Lencioni, Riccardo; Poon, R. T.

In: Annals of Surgical Oncology, Vol. 15, No. 4, 04.2008, p. 993-1000.

Research output: Contribution to journalArticle

Belghiti, J, Carr, BI, Greig, PD, Lencioni, R & Poon, RT 2008, 'Treatment before liver transplantation for HCC', Annals of Surgical Oncology, vol. 15, no. 4, pp. 993-1000. https://doi.org/10.1245/s10434-007-9787-8
Belghiti J, Carr BI, Greig PD, Lencioni R, Poon RT. Treatment before liver transplantation for HCC. Annals of Surgical Oncology. 2008 Apr;15(4):993-1000. https://doi.org/10.1245/s10434-007-9787-8
Belghiti, J. ; Carr, B. I. ; Greig, P. D. ; Lencioni, Riccardo ; Poon, R. T. / Treatment before liver transplantation for HCC. In: Annals of Surgical Oncology. 2008 ; Vol. 15, No. 4. pp. 993-1000.
@article{f9a476b7fc6a4984a11e4b55aece968b,
title = "Treatment before liver transplantation for HCC",
abstract = "Liver transplantation (LT) which is currently an established therapy for sma1l, early stage hepatocellular carcinoma (HCC) in patients with cirrhosis requires in most cases long waiting period. Tumor development during the waiting period may be associated with vascular invasion which is a strong factor of postoperative recurrence. Therefore, local treatment of the tumor including trans-arterial chemoembolization (TACE), percutaneous radiofrequency (RF) or partial liver resection can be used before transplantation. In the present paper we reviewed the efficacy of these treatments prior to LT. Although, TACE induced complete tumor necrosis in some patients there is no convincing arguments showing that this treatment reduces the rate of drop out before LT, nor improves the survival after LT. Although, RF can induce complete necrosis in the majority of small tumors (",
keywords = "Downstaging, Dropout, Hepatocellular carcinoma, Radiofrequency ablation, Resection, Transarterial chemoembolization, Transplantation",
author = "J. Belghiti and Carr, {B. I.} and Greig, {P. D.} and Riccardo Lencioni and Poon, {R. T.}",
year = "2008",
month = "4",
doi = "10.1245/s10434-007-9787-8",
language = "English (US)",
volume = "15",
pages = "993--1000",
journal = "Annals of Surgical Oncology",
issn = "1068-9265",
publisher = "Springer New York",
number = "4",

}

TY - JOUR

T1 - Treatment before liver transplantation for HCC

AU - Belghiti, J.

AU - Carr, B. I.

AU - Greig, P. D.

AU - Lencioni, Riccardo

AU - Poon, R. T.

PY - 2008/4

Y1 - 2008/4

N2 - Liver transplantation (LT) which is currently an established therapy for sma1l, early stage hepatocellular carcinoma (HCC) in patients with cirrhosis requires in most cases long waiting period. Tumor development during the waiting period may be associated with vascular invasion which is a strong factor of postoperative recurrence. Therefore, local treatment of the tumor including trans-arterial chemoembolization (TACE), percutaneous radiofrequency (RF) or partial liver resection can be used before transplantation. In the present paper we reviewed the efficacy of these treatments prior to LT. Although, TACE induced complete tumor necrosis in some patients there is no convincing arguments showing that this treatment reduces the rate of drop out before LT, nor improves the survival after LT. Although, RF can induce complete necrosis in the majority of small tumors (

AB - Liver transplantation (LT) which is currently an established therapy for sma1l, early stage hepatocellular carcinoma (HCC) in patients with cirrhosis requires in most cases long waiting period. Tumor development during the waiting period may be associated with vascular invasion which is a strong factor of postoperative recurrence. Therefore, local treatment of the tumor including trans-arterial chemoembolization (TACE), percutaneous radiofrequency (RF) or partial liver resection can be used before transplantation. In the present paper we reviewed the efficacy of these treatments prior to LT. Although, TACE induced complete tumor necrosis in some patients there is no convincing arguments showing that this treatment reduces the rate of drop out before LT, nor improves the survival after LT. Although, RF can induce complete necrosis in the majority of small tumors (

KW - Downstaging

KW - Dropout

KW - Hepatocellular carcinoma

KW - Radiofrequency ablation

KW - Resection

KW - Transarterial chemoembolization

KW - Transplantation

UR - http://www.scopus.com/inward/record.url?scp=40549118488&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=40549118488&partnerID=8YFLogxK

U2 - 10.1245/s10434-007-9787-8

DO - 10.1245/s10434-007-9787-8

M3 - Article

C2 - 18236111

AN - SCOPUS:40549118488

VL - 15

SP - 993

EP - 1000

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

IS - 4

ER -