Travel Surveillance and Genomics Uncover a Hidden Zika Outbreak during the Waning Epidemic

GeoSentinel Surveillance Network

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The Zika epidemic in the Americas has challenged surveillance and control. As the epidemic appears to be waning, it is unclear whether transmission is still ongoing, which is exacerbated by discrepancies in reporting. To uncover locations with lingering outbreaks, we investigated travel-associated Zika cases to identify transmission not captured by reporting. We uncovered an unreported outbreak in Cuba during 2017, a year after peak transmission in neighboring islands. By sequencing Zika virus, we show that the establishment of the virus was delayed by a year and that the ensuing outbreak was sparked by long-lived lineages of Zika virus from other Caribbean islands. Our data suggest that, although mosquito control in Cuba may initially have been effective at mitigating Zika virus transmission, such measures need to be maintained to be effective. Our study highlights how Zika virus may still be “silently” spreading and provides a framework for understanding outbreak dynamics. Video Abstract: [Formula presented] A combination of travel surveillance and clinical virus genomic sequencing of infected travelers provides a framework for detecting hidden outbreaks, such as an unreported Zika outbreak in Cuba during 2017.

Original languageEnglish (US)
Pages (from-to)1057-1071.e11
JournalCell
Volume178
Issue number5
DOIs
StatePublished - Aug 22 2019

Keywords

  • Zika epidemic
  • Zika virus
  • clinical sequencing
  • genomic epidemiology
  • infectious disease genomics
  • phylogenetics
  • travel surveillance
  • virus sequencing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Travel Surveillance and Genomics Uncover a Hidden Zika Outbreak during the Waning Epidemic'. Together they form a unique fingerprint.

Cite this