Traumatic Brain Swelling in Head Injured Patients: Brain Edema or Vascular Engorgement?

A. Marmarou, P. Barzo, P. Fatouros, T. Yamamoto, Ross Bullock, H. Young

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Brain edema and vascular engorgement have been used interchangeably to describe brain swelling associated with severe brain trauma and their relative contribution of these compartments to the swelling process remains controversial. In this report, imaging techniques for measurement of brain water and blood volume have been used to study the relative contribution of blood volume and tissue water to the swelling process in severely brain injured patients. More specifically, magnetic resonance techniques for non-invasive tissue water measures founded on mathematical models and later substantiated in laboratory and clinical studies were used for measure of brain tissue water. These studies were combined with measures of cerebral blood volume utilizing indicator dilution methods. Studies indicated that brain water was increased while blood volume decreased. These studies provide compelling evidence that the major contributor to brain swelling is brain edema and not blood volume. Therapies should now be targeted toward preventing edema development and enhancing edema resolution.

Original languageEnglish
Pages (from-to)68-70
Number of pages3
JournalActa Neurochirurgica, Supplement
Volume1997
Issue number70
StatePublished - Dec 1 1997
Externally publishedYes

Fingerprint

edema
Brain Edema
swelling
brain
Blood Vessels
Swelling
Brain
Blood Volume
Head
blood volume
Water
Blood
Edema
water
Tissue
Theoretical Models
Magnetic Resonance Spectroscopy
compartments
Magnetic resonance
imaging techniques

Keywords

  • Brain edema
  • Brain swelling
  • Traumatic brain edema
  • Vascular engorgement

ASJC Scopus subject areas

  • Medicine(all)
  • Clinical Neurology

Cite this

Marmarou, A., Barzo, P., Fatouros, P., Yamamoto, T., Bullock, R., & Young, H. (1997). Traumatic Brain Swelling in Head Injured Patients: Brain Edema or Vascular Engorgement? Acta Neurochirurgica, Supplement, 1997(70), 68-70.

Traumatic Brain Swelling in Head Injured Patients : Brain Edema or Vascular Engorgement? / Marmarou, A.; Barzo, P.; Fatouros, P.; Yamamoto, T.; Bullock, Ross; Young, H.

In: Acta Neurochirurgica, Supplement, Vol. 1997, No. 70, 01.12.1997, p. 68-70.

Research output: Contribution to journalArticle

Marmarou, A, Barzo, P, Fatouros, P, Yamamoto, T, Bullock, R & Young, H 1997, 'Traumatic Brain Swelling in Head Injured Patients: Brain Edema or Vascular Engorgement?', Acta Neurochirurgica, Supplement, vol. 1997, no. 70, pp. 68-70.
Marmarou A, Barzo P, Fatouros P, Yamamoto T, Bullock R, Young H. Traumatic Brain Swelling in Head Injured Patients: Brain Edema or Vascular Engorgement? Acta Neurochirurgica, Supplement. 1997 Dec 1;1997(70):68-70.
Marmarou, A. ; Barzo, P. ; Fatouros, P. ; Yamamoto, T. ; Bullock, Ross ; Young, H. / Traumatic Brain Swelling in Head Injured Patients : Brain Edema or Vascular Engorgement?. In: Acta Neurochirurgica, Supplement. 1997 ; Vol. 1997, No. 70. pp. 68-70.
@article{9686870ea04444318d84200bcbe0a84f,
title = "Traumatic Brain Swelling in Head Injured Patients: Brain Edema or Vascular Engorgement?",
abstract = "Brain edema and vascular engorgement have been used interchangeably to describe brain swelling associated with severe brain trauma and their relative contribution of these compartments to the swelling process remains controversial. In this report, imaging techniques for measurement of brain water and blood volume have been used to study the relative contribution of blood volume and tissue water to the swelling process in severely brain injured patients. More specifically, magnetic resonance techniques for non-invasive tissue water measures founded on mathematical models and later substantiated in laboratory and clinical studies were used for measure of brain tissue water. These studies were combined with measures of cerebral blood volume utilizing indicator dilution methods. Studies indicated that brain water was increased while blood volume decreased. These studies provide compelling evidence that the major contributor to brain swelling is brain edema and not blood volume. Therapies should now be targeted toward preventing edema development and enhancing edema resolution.",
keywords = "Brain edema, Brain swelling, Traumatic brain edema, Vascular engorgement",
author = "A. Marmarou and P. Barzo and P. Fatouros and T. Yamamoto and Ross Bullock and H. Young",
year = "1997",
month = "12",
day = "1",
language = "English",
volume = "1997",
pages = "68--70",
journal = "Scientific Computing and Instrumentation",
issn = "1078-8956",
publisher = "Springer Wien",
number = "70",

}

TY - JOUR

T1 - Traumatic Brain Swelling in Head Injured Patients

T2 - Brain Edema or Vascular Engorgement?

AU - Marmarou, A.

AU - Barzo, P.

AU - Fatouros, P.

AU - Yamamoto, T.

AU - Bullock, Ross

AU - Young, H.

PY - 1997/12/1

Y1 - 1997/12/1

N2 - Brain edema and vascular engorgement have been used interchangeably to describe brain swelling associated with severe brain trauma and their relative contribution of these compartments to the swelling process remains controversial. In this report, imaging techniques for measurement of brain water and blood volume have been used to study the relative contribution of blood volume and tissue water to the swelling process in severely brain injured patients. More specifically, magnetic resonance techniques for non-invasive tissue water measures founded on mathematical models and later substantiated in laboratory and clinical studies were used for measure of brain tissue water. These studies were combined with measures of cerebral blood volume utilizing indicator dilution methods. Studies indicated that brain water was increased while blood volume decreased. These studies provide compelling evidence that the major contributor to brain swelling is brain edema and not blood volume. Therapies should now be targeted toward preventing edema development and enhancing edema resolution.

AB - Brain edema and vascular engorgement have been used interchangeably to describe brain swelling associated with severe brain trauma and their relative contribution of these compartments to the swelling process remains controversial. In this report, imaging techniques for measurement of brain water and blood volume have been used to study the relative contribution of blood volume and tissue water to the swelling process in severely brain injured patients. More specifically, magnetic resonance techniques for non-invasive tissue water measures founded on mathematical models and later substantiated in laboratory and clinical studies were used for measure of brain tissue water. These studies were combined with measures of cerebral blood volume utilizing indicator dilution methods. Studies indicated that brain water was increased while blood volume decreased. These studies provide compelling evidence that the major contributor to brain swelling is brain edema and not blood volume. Therapies should now be targeted toward preventing edema development and enhancing edema resolution.

KW - Brain edema

KW - Brain swelling

KW - Traumatic brain edema

KW - Vascular engorgement

UR - http://www.scopus.com/inward/record.url?scp=0031302531&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0031302531&partnerID=8YFLogxK

M3 - Article

C2 - 9416281

AN - SCOPUS:0031302531

VL - 1997

SP - 68

EP - 70

JO - Scientific Computing and Instrumentation

JF - Scientific Computing and Instrumentation

SN - 1078-8956

IS - 70

ER -