Trauma spectrum disorders

Christine Heim, J. Douglas Bremner, Charles Nemeroff

Research output: Chapter in Book/Report/Conference proceedingChapter

4 Scopus citations

Abstract

Exposure to trauma and pathological responses are influenced by genotype. Despite the inherent difficulties of studying the genetics of trauma-related disorders, the field has exhibited remarkable advances. Identification of polymorphisms in critical genes that influence neurotransmitter systems involved in the stress response is rapidly progressing and will elucidate the nature of gene-by-environment interactions that determine whether an individual develops a disorder in response to trauma. This chapter provides an overview of the status of genetic research on trauma spectrum disorders and discusses clinical implications.

Original languageEnglish
Title of host publicationPrinciples of Molecular Medicine
PublisherHumana Press
Pages1203-1210
Number of pages8
ISBN (Print)9781588292025
DOIs
StatePublished - Dec 1 2006
Externally publishedYes

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Keywords

  • Amygdala
  • comorbidity
  • depression
  • endopheno-type
  • gene-environment interaction
  • hippocampus
  • hypothalamic-pituitary-adrenal axis
  • neurobiology
  • polymorphisms
  • post-traumatic stress disorder
  • startle
  • trauma

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Heim, C., Bremner, J. D., & Nemeroff, C. (2006). Trauma spectrum disorders. In Principles of Molecular Medicine (pp. 1203-1210). Humana Press. https://doi.org/10.1007/978-1-59259-963-9_127