Abstract
Exposure to trauma and pathological responses are influenced by genotype. Despite the inherent difficulties of studying the genetics of trauma-related disorders, the field has exhibited remarkable advances. Identification of polymorphisms in critical genes that influence neurotransmitter systems involved in the stress response is rapidly progressing and will elucidate the nature of gene-by-environment interactions that determine whether an individual develops a disorder in response to trauma. This chapter provides an overview of the status of genetic research on trauma spectrum disorders and discusses clinical implications.
| Original language | English |
|---|---|
| Title of host publication | Principles of Molecular Medicine |
| Publisher | Humana Press |
| Pages | 1203-1210 |
| Number of pages | 8 |
| ISBN (Print) | 9781588292025 |
| DOIs | |
| State | Published - Dec 1 2006 |
| Externally published | Yes |
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Keywords
- Amygdala
- comorbidity
- depression
- endopheno-type
- gene-environment interaction
- hippocampus
- hypothalamic-pituitary-adrenal axis
- neurobiology
- polymorphisms
- post-traumatic stress disorder
- startle
- trauma
ASJC Scopus subject areas
- Medicine(all)
Cite this
Trauma spectrum disorders. / Heim, Christine; Bremner, J. Douglas; Nemeroff, Charles.
Principles of Molecular Medicine. Humana Press, 2006. p. 1203-1210.Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Trauma spectrum disorders
AU - Heim, Christine
AU - Bremner, J. Douglas
AU - Nemeroff, Charles
PY - 2006/12/1
Y1 - 2006/12/1
N2 - Exposure to trauma and pathological responses are influenced by genotype. Despite the inherent difficulties of studying the genetics of trauma-related disorders, the field has exhibited remarkable advances. Identification of polymorphisms in critical genes that influence neurotransmitter systems involved in the stress response is rapidly progressing and will elucidate the nature of gene-by-environment interactions that determine whether an individual develops a disorder in response to trauma. This chapter provides an overview of the status of genetic research on trauma spectrum disorders and discusses clinical implications.
AB - Exposure to trauma and pathological responses are influenced by genotype. Despite the inherent difficulties of studying the genetics of trauma-related disorders, the field has exhibited remarkable advances. Identification of polymorphisms in critical genes that influence neurotransmitter systems involved in the stress response is rapidly progressing and will elucidate the nature of gene-by-environment interactions that determine whether an individual develops a disorder in response to trauma. This chapter provides an overview of the status of genetic research on trauma spectrum disorders and discusses clinical implications.
KW - Amygdala
KW - comorbidity
KW - depression
KW - endopheno-type
KW - gene-environment interaction
KW - hippocampus
KW - hypothalamic-pituitary-adrenal axis
KW - neurobiology
KW - polymorphisms
KW - post-traumatic stress disorder
KW - startle
KW - trauma
UR - http://www.scopus.com/inward/record.url?scp=78751520044&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=78751520044&partnerID=8YFLogxK
U2 - 10.1007/978-1-59259-963-9_127
DO - 10.1007/978-1-59259-963-9_127
M3 - Chapter
AN - SCOPUS:78751520044
SN - 9781588292025
SP - 1203
EP - 1210
BT - Principles of Molecular Medicine
PB - Humana Press
ER -