Trauma spectrum disorders

Christine Heim; J. Douglas Bremner; Charles B. Nemeroff

doi:10.1007/978-1-59259-963-9_127

Trauma spectrum disorders

Christine Heim, J. Douglas Bremner, Charles B. Nemeroff

Research output: Chapter in Book/Report/Conference proceeding › Chapter

4 Scopus citations

Abstract

Exposure to trauma and pathological responses are influenced by genotype. Despite the inherent difficulties of studying the genetics of trauma-related disorders, the field has exhibited remarkable advances. Identification of polymorphisms in critical genes that influence neurotransmitter systems involved in the stress response is rapidly progressing and will elucidate the nature of gene-by-environment interactions that determine whether an individual develops a disorder in response to trauma. This chapter provides an overview of the status of genetic research on trauma spectrum disorders and discusses clinical implications.

Original language	English (US)
Title of host publication	Principles of Molecular Medicine
Publisher	Humana Press
Pages	1203-1210
Number of pages	8
ISBN (Print)	9781588292025
DOIs	https://doi.org/10.1007/978-1-59259-963-9_127
State	Published - Dec 1 2006
Externally published	Yes

Keywords

Amygdala
comorbidity
depression
endopheno-type
gene-environment interaction
hippocampus
hypothalamic-pituitary-adrenal axis
neurobiology
polymorphisms
post-traumatic stress disorder
startle
trauma

ASJC Scopus subject areas

Medicine(all)

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10.1007/978-1-59259-963-9_127

Cite this

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title = "Trauma spectrum disorders",

abstract = "Exposure to trauma and pathological responses are influenced by genotype. Despite the inherent difficulties of studying the genetics of trauma-related disorders, the field has exhibited remarkable advances. Identification of polymorphisms in critical genes that influence neurotransmitter systems involved in the stress response is rapidly progressing and will elucidate the nature of gene-by-environment interactions that determine whether an individual develops a disorder in response to trauma. This chapter provides an overview of the status of genetic research on trauma spectrum disorders and discusses clinical implications.",

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AU - Bremner, J. Douglas

AU - Nemeroff, Charles B.

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AB - Exposure to trauma and pathological responses are influenced by genotype. Despite the inherent difficulties of studying the genetics of trauma-related disorders, the field has exhibited remarkable advances. Identification of polymorphisms in critical genes that influence neurotransmitter systems involved in the stress response is rapidly progressing and will elucidate the nature of gene-by-environment interactions that determine whether an individual develops a disorder in response to trauma. This chapter provides an overview of the status of genetic research on trauma spectrum disorders and discusses clinical implications.

KW - Amygdala

KW - comorbidity

KW - depression

KW - endopheno-type

KW - gene-environment interaction

KW - hippocampus

KW - hypothalamic-pituitary-adrenal axis

KW - neurobiology

KW - polymorphisms

KW - post-traumatic stress disorder

KW - startle

KW - trauma

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SN - 9781588292025

SP - 1203

EP - 1210

BT - Principles of Molecular Medicine

PB - Humana Press

ER -

Trauma spectrum disorders

Abstract

Keywords

ASJC Scopus subject areas

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