Trauma, inflammation, cochlear implantation induced hearing loss and otoprotective strategies to limit hair cell death and hearing loss

Stefania Goncalves, Enrique Perez, Esperanza Bas, Christine T. Dinh, Thomas R Van De Water

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

Hair cells are highly sensitive units that in response to trauma, inflammation, and cochlear implantation activate different signaling pathways leading to hair cell death and hearing impairment. In this chapter we discuss the most recent literature regarding signaling pathways of hair cell loss, mechanisms and inflammatory responses after noise exposure and electrode insertion, and otoprotective strategies that can limit hair cell death and hearing loss.

Original languageEnglish (US)
Title of host publicationInflammatory Mechanisms in Mediating Hearing Loss
PublisherSpringer International Publishing
Pages165-187
Number of pages23
ISBN (Electronic)9783319925073
ISBN (Print)9783319925066
DOIs
StatePublished - Jul 18 2018

Keywords

  • Apoptosis
  • Cochlear drug delivery
  • Electrode insertion trauma
  • Foreign body reaction
  • Inflammatory process signaling molecules
  • Pharmacological treatment
  • Protective hypothermia

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

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    Goncalves, S., Perez, E., Bas, E., Dinh, C. T., & Van De Water, T. R. (2018). Trauma, inflammation, cochlear implantation induced hearing loss and otoprotective strategies to limit hair cell death and hearing loss. In Inflammatory Mechanisms in Mediating Hearing Loss (pp. 165-187). Springer International Publishing. https://doi.org/10.1007/978-3-319-92507-3_9