Transplantation strategies to promote repair of the injured spinal cord

Mary Bartlett Bunge, Damien D. Pearse

Research output: Contribution to journalArticlepeer-review

105 Scopus citations

Abstract

This review describes the results of the transplantation of Schwann cells and olfactory ensheathing glia in combination with other interventions. The complete transection injury model was used to test the combination of Schwann cell bridges with methylprednisolone, neurotrophins, or olfactory ensheathing glia. The contusion injury model was used to compare Schwann cell and olfactory ensheathing glia transplantation and to examine the results of combining Schwann cell transplants with elevated levels of cyclic adenosine monophosphate. The combination strategies were more effective than cell transplantation alone. The improved regeneration response usually involved a reduction in secondary tissue loss, axonal regeneration from brainstem neurons, an increase in myelinated fibers in the transplant, the exit of regenerated fibers from the transplant into the contiguous cord, and an improvement in locomotor function.

Original languageEnglish (US)
Pages (from-to)55-62
Number of pages8
JournalJournal of rehabilitation research and development
Volume40
Issue number4 SUPPL. 1
DOIs
StatePublished - 2003

Keywords

  • Central nervous system (CNS) regeneration
  • Contusion injury
  • Cyclic adenosine monophosphate
  • Methylprednisolone
  • Neurotrophins
  • Olfactory ensheathing glia
  • Raphespinal tract
  • Schwann cells
  • Spinal cord transection

ASJC Scopus subject areas

  • Rehabilitation
  • Health Professions(all)
  • Engineering(all)

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