Transplantation strategies to promote repair of the injured spinal cord

Mary B Bunge, Damien D Pearse

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

This review describes the results of the transplantation of Schwann cells and olfactory ensheathing glia in combination with other interventions. The complete transection injury model was used to test the combination of Schwann cell bridges with methylprednisolone, neurotrophins, or olfactory ensheathing glia. The contusion injury model was used to compare Schwann cell and olfactory ensheathing glia transplantation and to examine the results of combining Schwann cell transplants with elevated levels of cyclic adenosine monophosphate. The combination strategies were more effective than cell transplantation alone. The improved regeneration response usually involved a reduction in secondary tissue loss, axonal regeneration from brainstem neurons, an increase in myelinated fibers in the transplant, the exit of regenerated fibers from the transplant into the contiguous cord, and an improvement in locomotor function.

Original languageEnglish
Pages (from-to)55-62
Number of pages8
JournalJournal of Rehabilitation Research and Development
Volume40
Issue number4 SUPPL. 1
StatePublished - Jul 1 2003

Fingerprint

Spinal Cord Regeneration
Schwann Cells
Transplants
Repair
Transplantation
Cells
Neuroglia
Regeneration
Fibers
Contusions
Cell Transplantation
Methylprednisolone
Nerve Growth Factors
Wounds and Injuries
Cyclic AMP
Brain Stem
Neurons
Tissue

Keywords

  • Central nervous system (CNS) regeneration
  • Contusion injury
  • Cyclic adenosine monophosphate
  • Methylprednisolone
  • Neurotrophins
  • Olfactory ensheathing glia
  • Raphespinal tract
  • Schwann cells
  • Spinal cord transection

ASJC Scopus subject areas

  • Rehabilitation
  • Health Professions(all)
  • Engineering(all)

Cite this

Transplantation strategies to promote repair of the injured spinal cord. / Bunge, Mary B; Pearse, Damien D.

In: Journal of Rehabilitation Research and Development, Vol. 40, No. 4 SUPPL. 1, 01.07.2003, p. 55-62.

Research output: Contribution to journalArticle

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