Transplantation of the abdominal wall

David M. Levi, Andreas G. Tzakis, Tomoaki Kato, Juan Madariaga, Naveen K. Mittal, Jose Nery, Seigo Nishida, Phillip Ruiz

Research output: Contribution to journalArticle

245 Citations (Scopus)

Abstract

Background: Closure of the abdomen in patients undergoing intestinal transplantation can be extremely difficult, if not impossible. We describe our initial experience with abdominal wall allotransplantation to facilitate abdominal closure. Methods: We undertook nine cadaveric abdominal wall composite allograft transplants in eight patients. The graft's blood supply was based on the inferior epigastric vessels left in continuity with the donor femoral and iliac vessels. Skin biopsies were undertaken randomly and when rejection was suspected. Vessel patency was monitored by doppler ultrasound. Findings: Six patients have survived, five of whom have intact, viable abdominal wall grafts. Two patients have had a clinically mild episode of acute rejection of the skin of the abdominal wall that resolved with corticosteroid therapy. No clinically apparent graft-versus-host disease has been noted. Interpretation: Transplantation of an abdominal wall composite allograft can facilitate reconstruction and closure of the abdominal compartment in intestinal transplant recipients with complex abdominal wall defects.

Original languageEnglish
Pages (from-to)2173-2176
Number of pages4
JournalLancet
Volume361
Issue number9376
DOIs
StatePublished - Jun 28 2003

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Abdominal Wall
Transplantation
Transplants
Allografts
Doppler Ultrasonography
Skin
Graft vs Host Disease
Thigh
Abdomen
Adrenal Cortex Hormones
Tissue Donors
Biopsy

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Levi, D. M., Tzakis, A. G., Kato, T., Madariaga, J., Mittal, N. K., Nery, J., ... Ruiz, P. (2003). Transplantation of the abdominal wall. Lancet, 361(9376), 2173-2176. https://doi.org/10.1016/S0140-6736(03)13769-5

Transplantation of the abdominal wall. / Levi, David M.; Tzakis, Andreas G.; Kato, Tomoaki; Madariaga, Juan; Mittal, Naveen K.; Nery, Jose; Nishida, Seigo; Ruiz, Phillip.

In: Lancet, Vol. 361, No. 9376, 28.06.2003, p. 2173-2176.

Research output: Contribution to journalArticle

Levi, DM, Tzakis, AG, Kato, T, Madariaga, J, Mittal, NK, Nery, J, Nishida, S & Ruiz, P 2003, 'Transplantation of the abdominal wall', Lancet, vol. 361, no. 9376, pp. 2173-2176. https://doi.org/10.1016/S0140-6736(03)13769-5
Levi DM, Tzakis AG, Kato T, Madariaga J, Mittal NK, Nery J et al. Transplantation of the abdominal wall. Lancet. 2003 Jun 28;361(9376):2173-2176. https://doi.org/10.1016/S0140-6736(03)13769-5
Levi, David M. ; Tzakis, Andreas G. ; Kato, Tomoaki ; Madariaga, Juan ; Mittal, Naveen K. ; Nery, Jose ; Nishida, Seigo ; Ruiz, Phillip. / Transplantation of the abdominal wall. In: Lancet. 2003 ; Vol. 361, No. 9376. pp. 2173-2176.
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