Transplantation of parathyroid, adrenal cortex and adrenal medulla using procedures which successfully prolonged islet allograft survival

Camillo Ricordi, P. E. Lacy, J. V. Santiago, P. E. Cryer, V. Di Carlo

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Life-long hormone replacement therapy is today the only form of therapy for several endocrine insufficiencies. Transplantation of endocrine tissues could represent a more physiological approach to the treatment of different syndromes such as adrenal insufficiency, diabetes or hypoparathyroidism. Successful experimental islet transplantation across major histocompatibility barriers using cultural pretreatment of the insulin producing tissue in conjunction with temporary immunosuppression of the recipients, encouraged us to attempt similar approaches with parathyroids, adrenal cortex and adrenal medulla. Either bilateral parathyroidectomy or bilateral adrenalectomy were performed on the recipient rats before transplantation, followed by the implantation of parathyroid, adrenar cortica- or adrenal medullary tissue beneath the renal capsule. The tissue was transplanted either immediately after its dissection or after pretreatment with 1 week culture. Some of the recipients received a short term cyclosporine treatment. The results indicated that parathyroid and adrenal medulla transplants were often infiltrated by mononuclear cells 30 days after transplantation. In contrast, adrenal cortical tissue was well preserved 4 weeks after transplantation, without showing any sign of rejection when a combination of pre-transplant culture of the adrenal tissue and temporary cyclospprine treatment of the recipients was used.

Original languageEnglish
Pages (from-to)132-135
Number of pages4
JournalHormone and Metabolic Research
Volume25
Issue numberSUPPL.
StatePublished - Dec 1 1990
Externally publishedYes

Fingerprint

Adrenal Medulla
Adrenal Cortex
Allografts
Transplantation
Tissue
Transplants
Tissue Transplantation
Hypoparathyroidism
Islets of Langerhans Transplantation
Adrenal Insufficiency
Parathyroidectomy
Histocompatibility
Adrenalectomy
Hormone Replacement Therapy
Dissection
Therapeutics
Immunosuppression
Cyclosporine
Capsules
Medical problems

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology

Cite this

Transplantation of parathyroid, adrenal cortex and adrenal medulla using procedures which successfully prolonged islet allograft survival. / Ricordi, Camillo; Lacy, P. E.; Santiago, J. V.; Cryer, P. E.; Di Carlo, V.

In: Hormone and Metabolic Research, Vol. 25, No. SUPPL., 01.12.1990, p. 132-135.

Research output: Contribution to journalArticle

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