Transplantation of multipotent progenitors from the adult olfactory epithelium

Bradley J. Goldstein, Hengsheng Fang, Steven L. Youngentob, James E. Schwob

Research output: Contribution to journalArticle

54 Scopus citations

Abstract

Mammalian olfactory epithelium produces new neurons rapidly throughout adulthood. Here, we demonstrate that precursor cells harvested from the adult olfactory epithelium, when transplanted into the nasal mucosa of host rats exposed previously to an olfactotoxic gas, engraft and participate in neuroepithelial reconstitution. In contrast to their normal neuronal fate in situ, grafted precursors harvested from bulbectomized donors produced non- neuronal cells as well as neurons. These results demonstrate that epithelial precursors activated following olfactory bulbectomy are not irreversibly committed to making neurons. Thus, olfactory progenitors are subject to a form of feedback control in vivo that regulates the types of cells that they produce within a broader-than-neuronal repertoire.

Original languageEnglish (US)
Pages (from-to)1611-1617
Number of pages7
JournalNeuroreport
Volume9
Issue number7
DOIs
StatePublished - May 11 1998
Externally publishedYes

Keywords

  • Neural precursors
  • Olfactory epithelium
  • Regeneration
  • Transplantation

ASJC Scopus subject areas

  • Neuroscience(all)

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