Transplantation of human islets without immunosuppression

Barbara Ludwig, Andreas Reichel, Anja Steffen, Baruch Zimerman, Andrew V. Schally, Norman L. Block, Clark K. Colton, Stefan Ludwig, Stephan Kersting, Ezio Bonifacio, Michele Solimena, Zohar Gendler, Avi Rotem, Uriel Barkai, Stefan R. Bornstein

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142 Scopus citations

Abstract

Transplantation of pancreatic islets is emerging as a successful treatment for type-1 diabetes. Its current stringent restriction to patients with critical metabolic lability is justified by the long-Term need for immunosuppression and a persistent shortage of donor organs. We developed an oxygenated chamber system composed of immune-isolating alginate and polymembrane covers that allows for survival and function of islets without immunosuppression. A patient with type-1 diabetes received a transplanted chamber and was followed for 10 mo. Persistent graft function in this chamber system was demonstrated, with regulated insulin secretion and preservation of islet morphology and function without any immunosuppressive therapy. This approach may allow for future widespread application of cell-based therapies.

Original languageEnglish (US)
Pages (from-to)19054-19058
Number of pages5
JournalProceedings of the National Academy of Sciences of the United States of America
Volume110
Issue number47
DOIs
StatePublished - Nov 19 2013

ASJC Scopus subject areas

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    Ludwig, B., Reichel, A., Steffen, A., Zimerman, B., Schally, A. V., Block, N. L., Colton, C. K., Ludwig, S., Kersting, S., Bonifacio, E., Solimena, M., Gendler, Z., Rotem, A., Barkai, U., & Bornstein, S. R. (2013). Transplantation of human islets without immunosuppression. Proceedings of the National Academy of Sciences of the United States of America, 110(47), 19054-19058. https://doi.org/10.1073/pnas.1317561110