Transoral laser microsurgery in previously irradiated patients with laryngeal cancer

Marianne Abouyared, Rosemary Ojo, Christopher Fundakowski, Kaming Lo, Zoukaa B Sargi

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Purpose Early laryngeal cancer is successfully managed with transoral laser microsurgery. Previously radiated patients may experience more post-operative complications. We investigate disease-free survival and secondarily prolonged pain and chondronecrosis. Materials and methods Retrospective review of 52 patients undergoing transoral laser microsurgery after previous radiation. Results Mean disease-free survival was 36.7 months. Overall disease-free survival was 57.6% at 3-year and 48.4% at 5-year follow-up, with no significant difference between surgery within as opposed to after 60 months of radiation or within as opposed to after 12 months of radiation. Thirteen patients, all with surgery within 60 months of radiation, experienced prolonged pain. Twelve experienced chondronecrosis, all within 12 months of surgery. Conclusion Transoral laser microsurgery for early laryngeal cancer is an adequate therapeutic option in patients with history of radiation with comparable disease-free survival to other reports. Patients undergoing transoral laser microsurgery within 60 months of radiation treatment are more likely to experience prolonged pain.

Original languageEnglish
Pages (from-to)279-285
Number of pages7
JournalAmerican Journal of Otolaryngology - Head and Neck Medicine and Surgery
Volume35
Issue number3
DOIs
StatePublished - Jan 1 2014

Fingerprint

Laryngeal Neoplasms
Microsurgery
Lasers
Radiation
Disease-Free Survival
Pain
Therapeutics

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Transoral laser microsurgery in previously irradiated patients with laryngeal cancer. / Abouyared, Marianne; Ojo, Rosemary; Fundakowski, Christopher; Lo, Kaming; Sargi, Zoukaa B.

In: American Journal of Otolaryngology - Head and Neck Medicine and Surgery, Vol. 35, No. 3, 01.01.2014, p. 279-285.

Research output: Contribution to journalArticle

Abouyared, Marianne ; Ojo, Rosemary ; Fundakowski, Christopher ; Lo, Kaming ; Sargi, Zoukaa B. / Transoral laser microsurgery in previously irradiated patients with laryngeal cancer. In: American Journal of Otolaryngology - Head and Neck Medicine and Surgery. 2014 ; Vol. 35, No. 3. pp. 279-285.
@article{a09fc16d3aec4d1486cbe45cf243bb49,
title = "Transoral laser microsurgery in previously irradiated patients with laryngeal cancer",
abstract = "Purpose Early laryngeal cancer is successfully managed with transoral laser microsurgery. Previously radiated patients may experience more post-operative complications. We investigate disease-free survival and secondarily prolonged pain and chondronecrosis. Materials and methods Retrospective review of 52 patients undergoing transoral laser microsurgery after previous radiation. Results Mean disease-free survival was 36.7 months. Overall disease-free survival was 57.6{\%} at 3-year and 48.4{\%} at 5-year follow-up, with no significant difference between surgery within as opposed to after 60 months of radiation or within as opposed to after 12 months of radiation. Thirteen patients, all with surgery within 60 months of radiation, experienced prolonged pain. Twelve experienced chondronecrosis, all within 12 months of surgery. Conclusion Transoral laser microsurgery for early laryngeal cancer is an adequate therapeutic option in patients with history of radiation with comparable disease-free survival to other reports. Patients undergoing transoral laser microsurgery within 60 months of radiation treatment are more likely to experience prolonged pain.",
author = "Marianne Abouyared and Rosemary Ojo and Christopher Fundakowski and Kaming Lo and Sargi, {Zoukaa B}",
year = "2014",
month = "1",
day = "1",
doi = "10.1016/j.amjoto.2014.03.004",
language = "English",
volume = "35",
pages = "279--285",
journal = "American Journal of Otolaryngology - Head and Neck Medicine and Surgery",
issn = "0196-0709",
publisher = "W.B. Saunders Ltd",
number = "3",

}

TY - JOUR

T1 - Transoral laser microsurgery in previously irradiated patients with laryngeal cancer

AU - Abouyared, Marianne

AU - Ojo, Rosemary

AU - Fundakowski, Christopher

AU - Lo, Kaming

AU - Sargi, Zoukaa B

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Purpose Early laryngeal cancer is successfully managed with transoral laser microsurgery. Previously radiated patients may experience more post-operative complications. We investigate disease-free survival and secondarily prolonged pain and chondronecrosis. Materials and methods Retrospective review of 52 patients undergoing transoral laser microsurgery after previous radiation. Results Mean disease-free survival was 36.7 months. Overall disease-free survival was 57.6% at 3-year and 48.4% at 5-year follow-up, with no significant difference between surgery within as opposed to after 60 months of radiation or within as opposed to after 12 months of radiation. Thirteen patients, all with surgery within 60 months of radiation, experienced prolonged pain. Twelve experienced chondronecrosis, all within 12 months of surgery. Conclusion Transoral laser microsurgery for early laryngeal cancer is an adequate therapeutic option in patients with history of radiation with comparable disease-free survival to other reports. Patients undergoing transoral laser microsurgery within 60 months of radiation treatment are more likely to experience prolonged pain.

AB - Purpose Early laryngeal cancer is successfully managed with transoral laser microsurgery. Previously radiated patients may experience more post-operative complications. We investigate disease-free survival and secondarily prolonged pain and chondronecrosis. Materials and methods Retrospective review of 52 patients undergoing transoral laser microsurgery after previous radiation. Results Mean disease-free survival was 36.7 months. Overall disease-free survival was 57.6% at 3-year and 48.4% at 5-year follow-up, with no significant difference between surgery within as opposed to after 60 months of radiation or within as opposed to after 12 months of radiation. Thirteen patients, all with surgery within 60 months of radiation, experienced prolonged pain. Twelve experienced chondronecrosis, all within 12 months of surgery. Conclusion Transoral laser microsurgery for early laryngeal cancer is an adequate therapeutic option in patients with history of radiation with comparable disease-free survival to other reports. Patients undergoing transoral laser microsurgery within 60 months of radiation treatment are more likely to experience prolonged pain.

UR - http://www.scopus.com/inward/record.url?scp=84899958005&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84899958005&partnerID=8YFLogxK

U2 - 10.1016/j.amjoto.2014.03.004

DO - 10.1016/j.amjoto.2014.03.004

M3 - Article

C2 - 24674345

AN - SCOPUS:84899958005

VL - 35

SP - 279

EP - 285

JO - American Journal of Otolaryngology - Head and Neck Medicine and Surgery

JF - American Journal of Otolaryngology - Head and Neck Medicine and Surgery

SN - 0196-0709

IS - 3

ER -