Abstract
The presence of serotonin (5-HT) and the characteristecs of the phase-response curve for 5-HT indicate that 5-HT acts as a transmitter of circadian information in the Aplysia eye. Additional evidence for such a neurotransmitter role of 5-HT in the eye is presented. The isolated eye has the capacity to synthesize 5-HT from exogenous tryptophan. The receptors mediating the phase-shifting effects of 5-HT have a high affinity for 5-HT (threshold for phase shifting is ≤ 10-7 M). Also these receptors demonstrate a high degree of structural specificity for 5-HT. Some structurally similar indoles to 5-HT do not cause phase shifts (5-hydroxytryptophan, 5-hydroxyindoleacetic acid), whereas others (bufotenine, tryptamine, LSD) do cause phase shifts but are less effects than 5-HT. Furthermore phase shifts in the rhythm are not produced by other monoamine neurotransmitters (dopamine, octopamine) or acetylcholine. Changes in membrane conductance to Na+, Cl-, or Ca2+ do not appear to be involved in phase shifting by 5-HT. Since large reductions in extracellular Ca2+ did not affect phase shifting by 5-HT, 5HT is acting either directly on the circadian pacemaker cell(s) or on cells electronically coupled to the pacemaker cell(s).
| Original language | English |
|---|---|
| Journal | American Journal of Physiology - Regulatory Integrative and Comparative Physiology |
| Volume | 11 |
| Issue number | 2 |
| State | Published - Jan 1 1982 |
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ASJC Scopus subject areas
- Physiology
Cite this
Transmitterlike action of serotonin in phase shifting a rhythm for the Aplysia eye. / Corrent, G.; Eskin, A.
In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 11, No. 2, 01.01.1982.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Transmitterlike action of serotonin in phase shifting a rhythm for the Aplysia eye
AU - Corrent, G.
AU - Eskin, A.
PY - 1982/1/1
Y1 - 1982/1/1
N2 - The presence of serotonin (5-HT) and the characteristecs of the phase-response curve for 5-HT indicate that 5-HT acts as a transmitter of circadian information in the Aplysia eye. Additional evidence for such a neurotransmitter role of 5-HT in the eye is presented. The isolated eye has the capacity to synthesize 5-HT from exogenous tryptophan. The receptors mediating the phase-shifting effects of 5-HT have a high affinity for 5-HT (threshold for phase shifting is ≤ 10-7 M). Also these receptors demonstrate a high degree of structural specificity for 5-HT. Some structurally similar indoles to 5-HT do not cause phase shifts (5-hydroxytryptophan, 5-hydroxyindoleacetic acid), whereas others (bufotenine, tryptamine, LSD) do cause phase shifts but are less effects than 5-HT. Furthermore phase shifts in the rhythm are not produced by other monoamine neurotransmitters (dopamine, octopamine) or acetylcholine. Changes in membrane conductance to Na+, Cl-, or Ca2+ do not appear to be involved in phase shifting by 5-HT. Since large reductions in extracellular Ca2+ did not affect phase shifting by 5-HT, 5HT is acting either directly on the circadian pacemaker cell(s) or on cells electronically coupled to the pacemaker cell(s).
AB - The presence of serotonin (5-HT) and the characteristecs of the phase-response curve for 5-HT indicate that 5-HT acts as a transmitter of circadian information in the Aplysia eye. Additional evidence for such a neurotransmitter role of 5-HT in the eye is presented. The isolated eye has the capacity to synthesize 5-HT from exogenous tryptophan. The receptors mediating the phase-shifting effects of 5-HT have a high affinity for 5-HT (threshold for phase shifting is ≤ 10-7 M). Also these receptors demonstrate a high degree of structural specificity for 5-HT. Some structurally similar indoles to 5-HT do not cause phase shifts (5-hydroxytryptophan, 5-hydroxyindoleacetic acid), whereas others (bufotenine, tryptamine, LSD) do cause phase shifts but are less effects than 5-HT. Furthermore phase shifts in the rhythm are not produced by other monoamine neurotransmitters (dopamine, octopamine) or acetylcholine. Changes in membrane conductance to Na+, Cl-, or Ca2+ do not appear to be involved in phase shifting by 5-HT. Since large reductions in extracellular Ca2+ did not affect phase shifting by 5-HT, 5HT is acting either directly on the circadian pacemaker cell(s) or on cells electronically coupled to the pacemaker cell(s).
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M3 - Article
VL - 11
JO - American Journal of Physiology - Cell Physiology
JF - American Journal of Physiology - Cell Physiology
SN - 0363-6143
IS - 2
ER -