Transmitter release during repetitive stimulation: Selective changes produced by Sr2+ and Ba2+

Janet E. Zengel; Karl L. Magleby

doi:10.1126/science.17160

Transmitter release during repetitive stimulation: Selective changes produced by Sr²⁺ and Ba²⁺

Janet E. Zengel, Karl L. Magleby

Physiology & Biophysics

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The addition of Sr²⁺ or Ba²⁺ to the solution bathing the frog neuromuscular junction leads to an increased release of transmitter by each nerve impulse during and following repetitive stimulation. The mechanisms by which Sr²⁺ and Ba²⁺ increase release are not the same. Each ion appears to act selectively on a different process involved in transmitter release.

Original language	English (US)
Pages (from-to)	67-69
Number of pages	3
Journal	Science
Volume	197
Issue number	4298
DOIs	https://doi.org/10.1126/science.17160
State	Published - Jan 1 1977

ASJC Scopus subject areas

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abstract = "The addition of Sr2+ or Ba2+ to the solution bathing the frog neuromuscular junction leads to an increased release of transmitter by each nerve impulse during and following repetitive stimulation. The mechanisms by which Sr2+ and Ba2+ increase release are not the same. Each ion appears to act selectively on a different process involved in transmitter release.",

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