Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function

Vassilios Papadopoulos, Mario Baraldi, Tomás R. Guilarte, Thomas B. Knudsen, Jean Jacques Lacapère, Peter Lindemann, Michael D. Norenberg, David Nutt, Abraham Weizman, Ming Rong Zhang, Moshe Gavish

Research output: Contribution to journalArticle

1003 Scopus citations

Abstract

The peripheral-type benzodiazepine receptor or recognition site (PBR) is a widely distributed transmembrane protein that is located mainly in the outer mitochondrial membrane. The PBR binds to high-affinity drug ligands and cholesterol. Many functions are associated directly or indirectly with the PBR, including the regulation of cholesterol transport and the synthesis of steroid hormones, porphyrin transport and heme synthesis, apoptosis, cell proliferation, anion transport, regulation of mitochondrial functions and immunomodulation. Based on these functions, there are many potential clinical applications of PBR modulation, such as in oncologic, endocrine, neuropsychiatric and neurodegenerative diseases. Although 'PBR' is a widely used and accepted name in the scientific community, recent data regarding the structure and molecular function of this protein increasingly support renaming it to represent more accurately its subcellular role (or roles) and putative tissue-specific function (or functions). Translocator protein (18 kDa) is proposed as a new name, regardless of the subcellular localization of the protein.

Original languageEnglish (US)
Pages (from-to)402-409
Number of pages8
JournalTrends in Pharmacological Sciences
Volume27
Issue number8
DOIs
StatePublished - Aug 2006

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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    Papadopoulos, V., Baraldi, M., Guilarte, T. R., Knudsen, T. B., Lacapère, J. J., Lindemann, P., Norenberg, M. D., Nutt, D., Weizman, A., Zhang, M. R., & Gavish, M. (2006). Translocator protein (18 kDa): new nomenclature for the peripheral-type benzodiazepine receptor based on its structure and molecular function. Trends in Pharmacological Sciences, 27(8), 402-409. https://doi.org/10.1016/j.tips.2006.06.005