Translational research in inflammatory bowel disease

Maria T. Abreu, Miles P. Sparrow

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

The idiopathic inflammatory bowel diseases (IBDs), broadly classified as either Crohn's disease (CD) or ulcerative colitis (UC), are caused by a dysregulated mucosal immune response to a luminal antigen, possibly a bacterium, in a genetically predisposed host. A rapid expansion of knowledge in recent years has greatly increased our understanding of the pathophysiology of these disorders. For example, the relatively recent discovery of the NOD2 gene, a protein involved in bacterial sensing, has provided further evidence of the complex interplay between hosts and microbes in Crohn's disease. Significant recent advances have also occurred with the discovery of the role of Toll-like receptors and dendritic cells in the development of gut inflammation, and the role of proinflammatory cytokines in the development and potentiation of gut inflammation. This article presents an update on these key developments and emphasizes the translational aspects of research that are directly related to patient care.

Original languageEnglish (US)
Pages (from-to)1067-1073
Number of pages7
JournalMount Sinai Journal of Medicine
Volume73
Issue number8
StatePublished - Dec 1 2006
Externally publishedYes

Keywords

  • Adaptive immunity
  • Biological therapies
  • Crohn's disease
  • Inflammatory bowel disease
  • Innate immunity
  • Ulcerative colitis

ASJC Scopus subject areas

  • Medicine(all)

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